Short communicationNigrotectal projections in the monkey: An autoradiographic study☆
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Using rAAV2-retro in rhesus macaques: Promise and caveats for circuit manipulation
2020, Journal of Neuroscience MethodsCitation Excerpt :Although we observed retrograde labeling in most expected areas following rAAV2-retro injection, we, intriguingly, identified at least one brain area in every case (1–5) that appeared devoid of retrograde labeling, despite having well-established afferent projections to the rAAV2-retro injection site. For example, while classical tracer studies show strong projections from substantia nigra pars compacta to striatum (Carpenter and Peter, 1972; Haber et al., 2000) and substantia nigra pars reticulata to SC (Jayaraman et al., 1977; Beckstead and Frankfurter, 1982; May, 2006), we found no labeled cells in any subdivision of the substantia nigra following rAAV2-retro injection in striatum or SC (Cases 1; 3–5). Similarly, while classical tracer studies show strong projections from mediodorsal thalamus to FEF (Leichnetz and Goldberg, 1988), we found no labeled cells in mediodorsal thalamus following rAAV2-retro injection in FEF (Case 2).
Chemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour
2013, European Journal of PharmacologyCitation Excerpt :Defensive behaviours include defensive alertness (Uribe-Mariño et al., 2012; Biagioni et al., 2012), freezing (Fanselow, 1980; Zhang et al., 1990), escape responses (Panksepp, 1990; Coimbra and Brandão, 1993), tonic immobility (Menescal-de-Oliveira and Hoffmann, 1993), and affective defence (Hess and Bruger, 1943). Several reports suggest that interactions between nigro-tectal GABAergic pathways (Jayaraman et al., 1977; Grofová et al., 1978; Coimbra and Brandão, 1993) and the endogenous opioid peptide-mediated system play a role in the organisation of some emotional responses. Intra-tectal and tecto-nigral varicose neural pathways, which are rich in beta-endorphin and leu-enkephalin (Eichenberger et al., 2002; Osaki et al., 2003; Ribeiro et al., 2005), have been proposed as relevant connective links involved in the modulation of fear and panic attacks though their disinhibitory action on nigro-tectal pathways (Castellan-Baldan et al., 2006).
Shedding new light on the role of the basal ganglia-superior colliculus pathway in eye movements
2010, Current Opinion in NeurobiologyCitation Excerpt :The relationship between saccadic eye movements and neuronal activity in the nigra was first identified from recordings performed in cat and monkey [9,17–20]. Studies of saccadic eye movements emphasize the nigra due to its direct projections to the colliculus [21]. The nigra is thought to act as a gate permitting collicular burst neurons (predorsal bundle neurons) to signal the brainstem thereby generating saccadic eye movements [22,23].
Brainstem sources of input to the central mesencephalic reticular formation in the macaque
2023, Experimental Brain ResearchObjective assessment of eye alignment and disparity-driven vergence in Parkinson’s disease
2023, Frontiers in Aging Neuroscience
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This investigation was supported by Grant NS-13750-01 from the National Institute of Neurological and Communicative Disorders and Stroke of the National Institutes of Health.
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A. Jayaraman, special fellow in neuroanatomy supported by Training Grant NS-05242-19 from the National Institute of Neurological and Communicative Disorders and Stroke.