Elsevier

Brain Research

Volume 155, Issue 1, 20 October 1978, Pages 108-112
Brain Research

The effects of puberty and castration on hippocampal dendritic spines of mice. A Golgi study

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  • α4βδ GABA <inf>A</inf> Receptors Trigger Synaptic Pruning and Reduce Dendritic Length of Female Mouse CA3 Hippocampal Pyramidal Cells at Puberty

    2019, Neuroscience
    Citation Excerpt :

    Adolescent pruning is thought to play a critical role in developing optimal levels of cognition in adulthood because it is disrupted in disorders such as autism (Hutsler and Zhang, 2010) and schizophrenia (van Spronsen and Hoogenraad, 2010), where cognition is impaired (D'Cruz et al., 2013). Many studies have documented this process in areas such as the CA1 hippocampus (Meyer et al., 1978; Yildirim et al., 2008; Afroz et al., 2016) and prefrontal cortex (Huttenlocher, 1979; Petanjek et al., 2011) where spine density decreases by half in adolescence. Studies have also documented that decreases in spines (Meyer and Ferres-Torres, 1978) and synapses (Shi et al., 2015) of CA3 hippocampal pyramidal cells occur in adolescence but these are limited to the male rodent where neither the spine types involved nor the underlying mechanism are known.

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