Spontaneous generalized spike-wave discharges in the electrocorticograms of albino rats
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Cited by (51)
Seizure Mimics
2017, Models of Seizures and Epilepsy: Second EditionThe developmental evolution of the seizure phenotype and cortical inhibition in mouse models of juvenile myoclonic epilepsy
2015, Neurobiology of DiseaseCitation Excerpt :Both Hetα1KO and Hetα1AD mice exhibited abundant SWDs and absence-like seizures at P35 and P120 (Fig. 2, Table 2). The morphology of the SWDs in both genotypes at both time-points matched those we reported previously in P35 Hetα1KO (Arain et al., 2012) and those that have been reported for rat SWD and AS (Akman et al., 2010; Robinson and Gilmore, 1980; Sitnikova and van Luijtelaar, 2007). Specifically, each SWD consisted of very rhythmic, 6–8 Hz spikes, positive transients, and waves (Figs. 2C–D).
Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy
2014, Epilepsy and BehaviorCitation Excerpt :The least severe seizure is stage 1 and includes a frozen posture with mouth and facial movements. Stage 2 corresponds to small movements of the head, such as head nodding [25]. If the strain that is used for studies of TLE naturally develops SWDs in adulthood, investigators have a possible confound when they try to address the emergence of epilepsy in animals at that age.
Animal models of absence epilepsies: What do they model and do sex and sex hormones matter?
2014, Neurobiology of DiseaseCitation Excerpt :Interestingly, a higher female prevalence can be inferred from the first paper of the Strasbourg Wistar rats (Vergnes et al., 1982), later named GAERS, when the rats were not fully inbred and not genetically homozygous for all autosomal genes. The presence of SWDs is not unique for GAERS and WAG/Rij rats; other outbred and inbred strains are endowed with SWDs, including some Wistar, Long-Evans, Sprague–Dawley, Fisher 344, G/Cpb and Brown Norway (BN) rats, although the incidence is generally lower than in the two established models (Kleinlogel, 1995; Robinson and Gilmore, 1980; Willoughby and Mackenzie, 1992; Inoue et al., 1990; Jandó et al., 1995). Few or no sex effects were studied in any of these rat lines, with only a few exceptions.
Auditory evoked potentials from auditory cortex, medial geniculate nucleus, and inferior colliculus during sleep-wake states and spike-wave discharges in the WAG/Rij rat
2001, Brain ResearchCitation Excerpt :Firstly, SWDs are a rather common phenomenon in the EEG of rodents [22]. Many different outbred and inbred rat strains and selection lines show SWDs, although they vary in the number of individuals that are affected and in the hourly number of SWDs being displayed [6,11,19,24,38,53,55]. What makes the WAG/Rij rat suitable as a model for absence epilepsy is that all individuals show a high incidence of SWDs.