Elsevier

Brain Research

Volume 269, Issue 2, 20 June 1983, Pages 347-351
Brain Research

A direct projection from the perirhinal cortex (area 35) to the subiculum in the rat

https://doi.org/10.1016/0006-8993(83)90144-0Get rights and content

Abstract

An efferent projection from the perirhinal cortex (area 35) in the rat was studied using the anterograde transport of triated amino acids as well as horseradish peroxidase (HRP). Following injections of either tracer in either the dorsal or ventral parts of area 35, anterogradely transported label was observed in the molecular layer of the subiculum, adjacent prosubiculum and CAla. Regardless of the dorsoventral level of the injection, the label was most dense at mid-dorsoventral levels of the subiculum and decreased in density in both the septal and temporal directions. Small injections of the same tracers made into the surrounding entorhinal, ectorhinal or prepiriform cortices did not reproduce this pattern. While the entorhinal cortex is the main cortical source of afferent input to the molecular layer of the subiculum as well as the hippocampus and dentate gyrus, the perirhinal cortex appears to constitute a complementary cortical pathway for afferent input to the subiculum.

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This research was supported by Grant NS 14944 to G.W.V.H. and BNS 79-214099 to D.L.R.

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The authors wish to thank the staff of both laboratories for their technical assistance.

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