Progesterone 5α-reductase in mouse brain
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Cited by (26)
Female mice with deletion of Type One 5α-reductase have reduced reproductive responding during proestrus and after hormone-priming
2014, Pharmacology Biochemistry and BehaviorCitation Excerpt :Expression of these steroidogenic enzymes varies across brain regions, but is high in areas, such as the midbrain ventral tegmental area (VTA). Greater 5α-reductase activity has been demonstrated in the midbrain versus preoptic area of the hypothalamus, hippocampus and cortex of mice (Roselli and Snipes, 1984), and a similar pattern of high 5α-reductase in the midbrain of rats has been reported (Li et al., 1997). The midbrain VTA has been our focus for the non-genomic, rapid effects of P4 and 3α,5α-THP for lordosis of mice (Frye and Vongher, 1999) and other rodent species (reviewed in Frye, 2011).
Localization of brain 5α-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity
2011, AlcoholCitation Excerpt :Both are expressed in the brain, but Srd5a2 is present only during a restricted perinatal period in rodents, whereas Srd5a1 is present throughout the development and adulthood (e.g., Melcangi et al., 1998). Kinetic properties and substrate specificity suggest that progesterone is actually the preferential substrate for 5α-reductase (Andersson and Russell, 1990; Roselli and Snipes, 1984). Once the irreversible conversion of progesterone to 5α-dihydroprogesterone takes place, the reduced progesterone metabolite can be further converted to the neurosteroid 3α-hydroxy-5α-pregnan-20-one (allopregnanolone [ALLO]) via the enzyme 3α-hydroxysteroid dehydrogenase (e.g., Mellon, 1994).
The role of pregnane neurosteroids in ethanol withdrawal: Behavioral genetic approaches
2004, Pharmacology and Therapeutics
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Present address: Department of Reproductive Biology and Behaviour, Oregon Regional Primate Research Center, 505 N.W. 185th Avenue, Beaverton, OR 97006, U.S.A.