Elsevier

Brain Research

Volume 348, Issue 2, 2 December 1985, Pages 261-273
Brain Research

Inhibition of feline spinal cord dorsal horn neurons following electrical stimulation of nucleus paragigantocellularis lateralis. A comparison with nucleus raphe magnus

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Abstract

The effect of electrical stimulation applied to the nucleus paragigantocellularis lateralis (PGL) was assessed on the somatosensory responses of functionally identified spinal cord dorsal horn neurons in the cat. Neurons were classified as low thershold mechanoreceptive, wide dynamic range or nociceptive specific. The responses of over 95% of all neurons tested were inhibited by a conditioning stimulus to the PGL. For each cell the threshold current intensity necessary to produce inhibition from the PGL (inhibitory threhold) was determined. Analysis of the incidence of inhibition and the inhibitory thresholds showed that the PGL-induced inhibition was not selective for a particular class of neuron. Due to the many similarities between the PGL and the nucleus raphe magnus (NRM), a comparison was made between each region's potency in inhibiting the responses of spinal cord neurons. Based on an analysis of inhibitory thresholds, the PGL was found to be significantly more potent than the NRM. These results indicate the PGL to be an important site from which descending modulation of spinal cord somesthetic information emanates.

References (91)

  • GallagerD.W. et al.

    Afferents to brain stem nuclei (brain stem raphe, nucleus reticularis pontis caudalis and nucleus gigantocellularis) in the rat as demonstrated by microiontophoretically applied horseradish peroxidase

    Brain Research

    (1978)
  • GebhartG.F. et al.

    An evaluation of stimulation-produced analgesia in the cat

    Exp. Neurol.

    (1978)
  • GuilbaudG. et al.

    Effects induced by stimulation of the centralis inferior nucleus of the raphe on dorsal interneurons in the cat's spinal cord

    Brain Research

    (1977)
  • HayesR.L. et al.

    Suppression of nociceptive responses in the primate by electrical stimulation of the brain or morphine administration: behavioral and electrophysiological comparisons

    Brain Research

    (1979)
  • HelkeC.J. et al.

    Substance P neurons project from the ventral medulla to the intermediolateral cell column and ventral horn in the rat

    Brain Research

    (1982)
  • HokfeltT. et al.

    Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system

    Neuroscience

    (1978)
  • HokfeltT. et al.

    Evidence for enkephalin immunoreactive neurons in the medulla oblongata projecting to the spinal cord

    Neurosci. Lett.

    (1979)
  • HolstegeG. et al.

    The anatomy of brain stem pathways to the spinal cord in the cat. A labeled amino acid tracing study

  • HuntS.P. et al.

    The distribution of serotonin, Met-enkephalin and B-lipotropin-like immunoreactivity in neuronal perikarya of the cat brainstem

    Neurosci. Lett.

    (1982)
  • JohanssonO. et al.

    Immunohistochemical support for three putative transmitters in one neuron: coexistence of 5-hydroxytryptamine, substance P- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord

    Neuroscience

    (1981)
  • JurnaI.

    Effect of stimulation in the periaqueductal grey matter on activity in ascending axons of the rat spinal cord: selective inhibition of activity evoked by afferent Aδ and C fibre stimulation and failure of naloxone to reduce inhibition

    Brain Research

    (1980)
  • KneisleyL.W. et al.

    A study of the origin of brain stem projections to monkey spinal cord using the retrograde transport method

    Exp. Neurol.

    (1978)
  • KuypersH.G.J.M. et al.

    Retrograde axonal transport of horseradish peroxidase from spinal cord to brain stem cell groups in the cat

    Neurosci. Lett.

    (1975)
  • KuypersH.G.J.M. et al.

    Funicular trajectories of descending brainstem pathways in cats

    Brain Research

    (1977)
  • LoeschckeH.H. et al.

    Effects on respiration and circulation of electrically stimulating the ventral surface of medullar oblongata

    Respir. Physiol.

    (1970)
  • LoewyA.D. et al.

    Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat

    Brain Research

    (1981)
  • LoewyA.D. et al.

    Efferent connections of the ventral medulla oblongata in the rat

    Brain Res. Rev.

    (1981)
  • LovickT.A. et al.

    Substance P-immunoreactive and serotonin-containing neurones in the ventral brainstem of the cat

    Neurosci. Lett.

    (1983)
  • LovickT.A. et al.

    Responses of raphe spinal and other bulbar raphe neurones to stimulation of the periaqueductal gray in the cat

    Neurosci. Lett.

    (1978)
  • LovickT.A. et al.

    Projections from brain stem nuclei to the spinal trigeminal nucleus in the cat

    Neuroscience

    (1983)
  • MantyhP.W. et al.

    Evidence for cholecystokinin-like immunoreactive neurons in the rat medulla oblongata which project to the spinal cord

    Brain Research

    (1984)
  • MantyhP.W. et al.

    Spinal projections from the periaqueductal grey and dorsal raphe in the rat, cat and monkey

    Neuroscience

    (1982)
  • MayerD.J. et al.

    Pain reduction by focal electrical stimulation of the brain: an anatomical and behavioral analysis

    Brain Research

    (1974)
  • MohrlandJ.S. et al.

    Effects of focal electrical stimulation and morphine microinjection in the periaqueductal gray of the rat mesencephalon on neuronal activity in the medullary reticular formation

    Brain Research

    (1980)
  • OliverasJ.L. et al.

    Analgesia induced by electrical stimulation of the inferior centralis nucleus of the raphe in the cat

    Pain

    (1975)
  • PriceD.D. et al.

    Neurons that subserve the sensory-discriminative aspects of pain

    Pain

    (1977)
  • ProudfitH.K. et al.

    The role of GABA and serotonin in the mediation of raphe-evoked spinal cord dorsal root potentials

    Brain Research

    (1980)
  • RanckJ.B.

    Which elements are excited in electrical stimulation of mammalian central nervous system: a review

    Brain Research

    (1975)
  • RivotJ.P. et al.

    Increase in serotonin metabolism within the dorsal horn of the spinal cord during nucleus raphe magnus stimulation, as revealed by in vivo electrochemical detection

    Brain Research

    (1982)
  • SatohM. et al.

    Evidence for involvement of separate mechanisms in the production of analgesia by electrical stimulation of the nucleus reticularis paragigantocellularis and nucleus raphe magnus in the rat

    Brain Research

    (1980)
  • SessleB.J. et al.

    Suppressive influences from periaqueductal gray and nucleus raphe magnus on respiration and related reflex activities and on solitary tract neurons, and effect of naloxone

    Brain Research

    (1981)
  • ShahY. et al.

    Electrophysiological evidence for a projection of the periaqueductal gray matter to nucleus raphe magnus in cat and rat

    Brain Research

    (1980)
  • SoperW.Y. et al.

    Stimulation-produced analgesia: evidence for somatotopic organization in the midbrain

    Brain Research

    (1982)
  • TakagiH. et al.

    Analgesia by enkephalins injected into the nucleus reticularis gigantocellularis of rat medulla oblongata

    Eur. J. Pharmacol.

    (1978)
  • TaubA.

    Local, segmental and supraspinal interaction with a dorsolateral spinal cutaneous afferent system

    Exp. Neurol.

    (1964)
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