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2019, Veterinary Anaesthesia and AnalgesiaCitation Excerpt :There appears to be a supra-additive effect between morphine and maropitant that could be due to their action on inhibiting the effects of substance P at the spinal level. Substance P is one of the neurotransmitters released by nociceptive primary afferents of the C fibres after noxious thermal stimulus (Duggan et al. 1987) which binds to neurokinin (NK1) receptors (IUPHAR/BPS 2018). Depletion of primary afferent substance P resulted in substantial thermal antinociception in Guinea pigs (Buck et al. 1981) and increased tail-flick and hot-plate thresholds in adult rats (Nagy et al. 1980).
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2018, Progress in NeurobiologyCitation Excerpt :To the present discussion CGRP is of particular relevance because it is highly expressed in DRG neurons and is, thus, a very useful and specific marker of PAF terminals in SGR. Despite the well know functions of the peptide peripheral projections in neurogenic vasodilatation, inflammation and modulation of the immune responses (Aggarwal et al., 2012; Holzmann, 2013), the central effects of CGRP remain somewhat elusive, although it has been long known that the peptide is released in the DH as a consequence of nociceptive PAF stimulation (Duggan et al., 1987; Morton and Hutchison, 1989) and evidence sustained its pronociceptive effects (Sun et al., 2003, 2004). From the very beginning, immunocytochemical localization studies confirmed the intense labeling of the SGR and the primary afferent origin of CGRP-IR fibers herein distributed in numerous mammals, including humans (Gibson et al., 1981; Gibson and Polak, 1986; Wall et al., 1981).
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