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Cited by (47)
Targeting the orexin system for prescription opioid use disorder: Orexin-1 receptor blockade prevents oxycodone taking and seeking in rats
2020, NeuropharmacologyCitation Excerpt :In the same study, the authors found that Orx gene expression was induced by opioid withdrawal (Georgescu et al., 2003). Moreover, mice self-administered morphine directly in the lateral hypothalamus (Cazala et al., 1987), and the activation of Orx neurons or application of Orx in the VTA reinstated morphine seeking (Harris et al., 2005). Therefore, SB334867 might decrease oxycodone self-administration and reinstatement through actions on the mesolimbic system.
Neurocircuitry of drug reward
2014, NeuropharmacologyCitation Excerpt :Rats and mice are found to self-administer morphine or muscimol into the septal area (Cazala et al., 1998; Gavello-Baudy et al., 2008; Stein and Olds, 1977). Opiates appear to be also self-administered into the lateral hypothalamic area (Cazala et al., 1987; Olds, 1979) and periaqueductal gray (David and Cazala, 1994). In summary, trigger regions identified by ICSA for reward include the VTA, RMTg, SuM and MnR.
Blockade of orexin receptor 1 attenuates the development of morphine tolerance and physical dependence in rats
2012, Pharmacology Biochemistry and BehaviorCitation Excerpt :Orexin which is expressed in thousands of neurons in the lateral hypothalamus (LH) shows an important role in the modulation of motivated behaviors (Peyron et al., 1998). Growing studies suggest that the LH has important roles in behaviors relating to drug dependence and reward: a) stronger intracranial self-stimulation compared to other brain regions (Gallistel et al., 1981); b) direct self-administration of morphine into the LH (Cazala et al., 1987); c) blockade of systemic heroin self-administration by microinjection of the opioid antagonist into the LH (Corrigall, 1987);, d) positive reinforcements of morphine microinjection into the LH (van der et al., 1982); e) attenuation of intracranial self-stimulation with LH lesion (Velley et al., 1983); and f) some recent studies have also reported that orexin neurons residing in the LH have a role in reward behaviors (Harris et al., 2005, 2007; Narita et al., 2006; Harris and Aston-Jones, 2006; Sharf et al., 2008; Aston-Jones et al., 2009). Georgescu et al. (2003) by using c-fos immunoreactivity and CRE-LacZ reporter activity demonstrated that the chronic morphine administration and precipitated withdrawal induce the transcription and neuronal plasticity in the LH orexin neurons whereas virtually no induction was seen in nearby LH neurons expressing the melanin-concentrating hormone.
Brain reward circuitry beyond the mesolimbic dopamine system: A neurobiological theory
2010, Neuroscience and Biobehavioral Reviews