Neurophysiological alterations in caudate neurons in aged cats
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Cited by (23)
Behavior Problems of the Senior Cat
2015, Feline Behavioral Health and WelfareClinical signs and management of anxiety, sleeplessness, and cognitive dysfunction in the senior pet
2011, Veterinary Clinics of North America - Small Animal PracticeCitation Excerpt :Laboratory studies have identified altered sleep-wake cycles, increased stereotypy, and decreased social contact with humans in dogs with cognitive impairment.54 In cats, based on more limited data, cognitive and motor performance seem to decline starting at approximately 10 to 11 years of age, but functional change in the neurons of the caudate nucleus have been seen by 6 to 7 years of age.55–57 To diagnose CDS, veterinarians must rely on owner history.
Cognitive dysfunction in cats. A syndrome we used to dismiss as 'old age'
2010, Journal of Feline Medicine and SurgeryAge-related alterations in responses of the nucleus basalis magnocellularis neurons to peripheral nociceptive stimuli
2002, Brain ResearchCitation Excerpt :The changes in excitatory activity of neurons in aged animals have been observed in several brain regions. Electrophysiological experiments in vivo of Levine and co-workers [22,23] revealed an increase in the threshold of excitatory or inhibitory responses and the decreases in spontaneous activity and proportion of excitatory responses evoked by cortex or substantia nigra stimulation in aged cats. Similar to caudate neurons in aged cats, cerebellar Purkinje neurons in aged rats also displayed slower discharge rates and reduced excitability to afferent fiber stimulation [34].