Elsevier

Brain Research

Volume 437, Issue 2, 29 December 1987, Pages 379-382
Brain Research

Short communication
Formation of new corticorubral synapses as a mechanism for classical conditioning in the cat

https://doi.org/10.1016/0006-8993(87)91656-8Get rights and content

Abstract

An electron microscopic quantitative study of corticorubral synapses was performed in the cat which acquired classical conditioning. Conditioned stimulus was applied to the cerebral peduncle and the unconditioned stimulus was an electrical shock to the forelimb skin. The proportion of corticorubral synapses contacting with somata and proximal dendrite was increased after conditioning. It was suggested that collateral sprouting and the formation of new synapses underlie classical conditioning.

References (11)

There are more references available in the full text version of this article.

Cited by (14)

  • Neuroprotective action of bacterial melanin in rats after corticospinal tract lesions

    2012, Pathophysiology
    Citation Excerpt :

    Thus, the different recovery periods of the operant conditioned reflex in transected animals treated and not treated with melanin provide evidence of acceleration of this process as a result of treatment with bacterial melanin. It remains possible that this involves acceleration of the processes of sprouting and new synapse formation [34]. The rapid and compete elimination of motor deficit (at 4–6 days with a dose of 6 mg/ml) seen in rats given melanin can be assigned to the activating effects of this substance.

  • The effect of brachium conjunctivum transection on a conditioned limb response in the cat

    2000, Behavioural Brain Research
    Citation Excerpt :

    Combined evidence from numerous studies of conditioned nictitating membrane and limb flexion responses in the rabbit and cat, respectively, suggest that premotor efferent control of conditioned associative learning involves a circuit including, but not necessarily restricted to cerebellum (nucleus interpositus and cortical lobule HVI) [13–15,21,26,31,32,34,39,41,42,47–50,56,58,59,61–64,73,81–83,85], inferior olivary nucleus [26,43,69,75,76,84], and the magnocellular red nucleus [2,16,20,23–25,37,44–46,54,57,60,66,74].

View all citing articles on Scopus

Supported in part by Grant-in-Aid for Special Project Research of Plasticity of Neural circuits from the Japanese Ministry of Education, Science and Culture.

1

We are grateful to Drs. Toshio Kosaka, Mitsuo Kawato and Yasuo Kawaguchi for critically reading the manuscript.

View full text