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Age- and sex-dependent effects of methamphetamine on cognitive flexibility and 5-HT<inf>2C</inf> receptor localization in the orbitofrontal cortex of Sprague-Dawley rats
2018, Behavioural Brain ResearchCitation Excerpt :Assessment of 5-HT2CR co-localization with PV-ir interneurons revealed that in the left hemisphere, adult-onset males with a history of METH self-administration had significantly higher co-localization than their age-matched controls and adolescent-onset males. The significant impact of hemisphere was not anticipated, but is consistent with a large body of literature demonstrating laterality of monoamine levels [72], receptor distribution [73–75], innervation [76], and function [76–78]. Increased co-expression of 5-HT2CRs with PV-ir interneurons in adult-onset males with a history of METH self-administration is consistent with previous studies demonstrating psychostimulant-induced changes in 5-HT2CRs [44,45,79] and PFC GABAergic interneurons [25,80–82].
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