Elsevier

Brain Research

Volume 453, Issues 1–2, 21 June 1988, Pages 381-384
Brain Research

Short communication
Differential sensitization to amphetamine and stress responsivity as a function of inherent laterality

https://doi.org/10.1016/0006-8993(88)90183-7Get rights and content

Abstract

With repeated administrations, rodents become increasingly sensitive to the stimulant properties of amphetamine, a phenomenon termed sensitization. Rats differentiated on the basis of their preferred direction of rotation following peripheral administration of amphetamine were found to differ in their sensitization to amphetamine in two different behavioral paradigms. Rats which displayed left-ward rotational biases developed greater sensitization and greater hormonal response to stress following sensitization.

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  • Cited by (0)

    1

    Present address: Department of Psychobiology, University of California, Irvine, CA 92717, U.S.A.

    2

    The authors are grateful to Mlle. R.M. Bluthé, Mme. C. Cauchois, and Mme. I. Batby for their excellent assistance, and to the National Institute of Arthritis, Diabetes and Digestive and Kidney Diseases (NIH, U.S.A.) for providing the reagents used for the PRL RIA. G.J.L. was an N.S.F.-C.N.R.S. Postdoctoral Fellow when these studies were conducted.

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