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2012, Journal of Psychiatric ResearchCitation Excerpt :Tolin and Villavicencio (2011) recently described that inattentive symptoms of ADHD predicted severity of clutter, difficulty in discarding and acquiring. The independent association of hoarding with tic disorders has been demonstrated by other authors (Baer, 1994; Millet et al., 2004; Diniz et al., 2006; Samuels et al., 2007) and suggests that the dopaminergic system may play a central role in hoarding, as already shown in animal studies (Kelley and Stinus, 1985; Herman et al., 1986; Kalsbeek et al., 1988). Interestingly, a recent heritability study (Mathews and Grados, 2011) demonstrated a strong genetic association of OCD with both TS and ADHD, but not between TS and ADHD.
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2010, AlcoholCitation Excerpt :The volume of PFC declines from adolescence to young adulthood (Sowell et al., 1999, 2001; van Eden et al., 1990), and this reduction is associated with both a refinement in the neural circuits and the connectivity. For instance, a loss of synapses, especially the excitatory glutamatergic inputs to the PFC, occurs during adolescence (Huttenlocher, 1984), whereas the dopamine (DA) and the serotonin (5-hydroxytryptamine) inputs to the PFC increase during adolescence and then decrease later in life (Kalsbeek et al., 1988; Rosenberg and Lewis, 1994). These remodeling changes in the neural circuits are associated with cognitive functional modifications and with the acquisition of executive functions (e.g., response inhibition, attention, working memory) (Casey et al., 2000; Paus, 2005).
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