Research reportUse of serotonin immunocytochemistry as a marker of injury severity after experimental spinal trauma in rats
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Gsx1 promotes locomotor functional recovery after spinal cord injury
2021, Molecular TherapySerotonergic mechanisms in spinal cord injury
2019, Experimental NeurologyTransplantation of neural progenitor cells in chronic spinal cord injury
2016, NeuroscienceCograft of neural stem cells and schwann cells overexpressing TrkC and neurotrophin-3 respectively after rat spinal cord transection
2011, BiomaterialsCitation Excerpt :Lastly, we did not detect Hoechst 33342 signal in cells adjacent to the lesion epicenter that had features of host neurons. Due to the fact that there was no indication of CST or RST regeneration based on neurofilament ICC (data not shown), we decided to focus on regional sprouting of serotonergic (5-HT) fibers from primary descending pathways of motosensory modulation in the mammalian spinal cord with known benefits to locomotion recovery [42–47]. Anti-5-HT ICC depicted that some serotonergic neurites were present inside the lesion site.
The time course of serotonin 2A receptor expression after spinal transection of rats: An immunohistochemical study
2011, NeuroscienceCitation Excerpt :Thus, the upregulation of 5-HT2AR in the lateral intermediate zone in the L1-2 segments is likely to be related with recovery of locomotion following a lesion since these segments contain critical elements of the locomotor central pattern generator (reviewed by Guertin, 2009) and 5-HT2AR have been shown to be critical for locomotor network activation (Ung et al., 2008; Halberstadt et al., 2009). The changes in 5-HT expression after spinalization in the present study are in agreement with previous biochemical and immunohistochemical studies (Anden et al., 1964; Clineschmidt et al., 1971; Magnusson, 1973; Hadjiconstantinou et al., 1984; Faden et al., 1988). Although intraspinal 5-HT neurons were reported to exist in the spinal cord even after spinal transection (Newton and Hamill, 1988; Kong et al., 2010), we did not detect any 5-HT fibers in the ventral horn motoneuron region in the analyzed sections in 21 days and 28 days spinalized animals.
Implantation of adult bone marrow-derived mesenchymal stem cells transfected with the neurotrophin-3 gene and pretreated with retinoic acid in completely transected spinal cord
2010, Brain ResearchCitation Excerpt :It is extremely possible these axons may come from the regenerative fibers, but not the differentiated foreign cells, since more 5-HT-postive axons of AdvNT-3-RA-MSC-implanted group were found in the lesion site than those of other cell-implanted groups. We believe this finding is important, since a strong correlation between 5-HT regeneration and locomotor recovery in transected SCI is well established (Faden et al., 1988; Saruhashi et al., 1996; Zhang et al., 2007). Experimental evidence indicates that certain 5-HT axons descending from the brain provide a direct, excitatory input to spinal motoneurons that innervate hindlimb muscles (Alvarez et al., 1998).