Elsevier

Brain Research

Volume 482, Issue 2, 20 March 1989, Pages 381-386
Brain Research

Evidence for a distinct nigropallidal dopaminergic projection in the squirrel monkey

https://doi.org/10.1016/0006-8993(89)91205-5Get rights and content

Abstract

Injections of the retrograde fluorescent tracer fast blue in the striatum (STR) and nuclear yellow in the internal segment of the globus pallidus (GPi) in the squirrel monkey (Saimiri sciureus) revealed a nigropallidal projection whose cellular origin was largely distinct from that of the nigrostriatal pathway. Neurons containing the tracer injected in GPi were scattered throughout the substantia nigra-ventral tegmental area complex where they formed approximately 20–25% of the total number of retrogradely labeled cells. Only about 5–10% of all positive neurons were double-labeled after STR-GPi injections. In experiments combining the use of the fluorescent tracer propidium iodide with immunofluorescence, the majority of neurons projecting to GPi displayed tyrosine hydroxylase immunoreactivity. Hence, in addition to their important role at striatal level, midbrain dopaminergic neurons may influence directly the output neurons of the basal ganglia at pallidal level in primates.

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This research was supported by grant MT-5781 of the Medical Research Council (MRC) of Canada to A.P. The financial support of the FRSQ and FCAR is also acknowledge.

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Present address: MRC Anatomical Pharmacology Unit, University Department of Pharmacology, South Park Road, Oxford, OX1 3QT, U.K.

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