Elsevier

Brain Research

Volume 504, Issue 2, 18 December 1989, Pages 211-215
Brain Research

Research report
Kinase inhibition lengthens the period of the circadian pacemaker in the eye of Bulla gouldiana

https://doi.org/10.1016/0006-8993(89)91359-0Get rights and content

Abstract

The inhibition of protein kinase activity by the isoquinoline sulfonamide, H-8, lengthens the period of the Bulla ocular circadian rhythm in a dose-dependent manner. In addition, the phosphorylation of 5 proteins is markedly affected by H-8. The observed correlation between H-8's period lengthening effects, and its effects on the phosphorylation of specific proteins, suggests that: (1) these proteins are candidate components regulating the period of the circadian rhythm; and (2) the dailychanges in membrane potential underlying the circadian rhythm are mediated by similar mechanisms that serve to change neural function in other systems; modulation of protein kinases.

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