Preservation of integrative function in a perfused guinea pig brain
References (74)
- et al.
Thyrotropin-releasing hormone: physiological concomitants of behavioral excitation
Pharmacol. Biochem. Behav.
(1977) - et al.
The classification and significance of electro-encephalographic patterns produced by nitrous oxide-ether anesthesia during surgical operations
- et al.
In vitro characterization of neurons in the ventral part of the nucleus tractus solitarius. II. Ionic basis for repetitive firing patterns
J. Neurophysiol.
(1987) - et al.
Fluorocarbon perfusion medium applied to the isolated rat brain
J. Pharmacol. Methods
(1980) - et al.
Changes in ultrastructure and synaptic transmission in the sympathetic ganglion during various metabolic conditions
Prog. Brain Res.
(1969) Metabolism of mammalian sympathetic ganglia
FC-43 Emulsion
(September 4, 1976)- et al.
Über die Erholung und Wiederbelebung des Gehirns nach Ischamie bei Normothermie
Pflügers Arch.
(1957) - et al.
An improved method for perfusion of the isolated brain of the rat — influence of perfusion conditions and application of analeptic and anticonvulsant drugs
J. Pharmacol. Methods
(1983) Monitoring
A unitary analysis of pulmonary volume receptors
Am. J. Physiol.
Isolated mammalian brain in vitro: new technique for analysis of electrical activity of neuronal circuit function
Neural Origin of Rhythmic Movements
Maturational changes in pressure gradients for glomerular filtration
Am. J. Physiol.
Some physiological aspects of analysis of frequency spectra of the EEG
Biomed. Sci. Instrum.
An isolated, perfused rat brain preparation, its spontaneous and stimulated activity
J. Appl. Physiol.
Origin and regulation of spontaneous deep breaths
Respir. Physiol.
Pattern of ventilation in young adults
J. Appl. Physiol.
Application of ultrasonic processors
American Biotechnology Laboratory
J. Physiol. Homme Anim. (Paris)
J. Exp. Med.
Characteristics and rate of occurrence of spontaneous and provoked augmented breaths
Acta Physiol. Scand.
On the regulation of depth and rate of breathing
J. Physiol. (Lond.)
Perfusion of whole animals with perfluorinated liquid emulsions using the Clark bubble-defoam heart-lung machine
Phrenic and recurrent laryngeal discharge patterns and the Hering-Breuer refles
Am. J. Physiol.
Convulsive activity in gerbils subjected to cerebral ischemia
Exp. Neurol.
Physical characteristics of the chest and lungs and the work of breathing in different mammalian species
J. Physiol. (Lond.)
Firing pattern of neurons in the nucleus tractus solitarius: modulation by membrane hyperpolarization
Brain Research
In vitro characterization of neurons in the ventral part of the nucleus tractus solitarius. I. Identification of neuronal types and repetitive firing properties
J. Neurophysiol.
Thyrotropin-releasing hormone induces rhythmic bursting in neurons of the nucleus tractus solitarius
Science
Perfusion of the cervical spinal cord in situ of adult rats using a perfluorocarbon emulsion
Brain Research
An improved apparatus for blood perfusion of the canine cerebral vasculature
Neurochem. Res.
Neurophysiology of breathing in mammals
Ischaemic paralysis of a uniform nerve
Acta Physiol. Scand.
Electrophysiological properties of neonatal rat motoneurones studied in vitro
J. Physiol. (Lond.)
Hypoxia
Isolation and mechanical maintenance of the dog brain
Nature (Lond.)
The role of the vagus nerves, peripheral chemoreceptors and other afferent pathways in the genesis of augmented breaths in cats and rabbits
Respir. Physiol.
Cited by (28)
An arterially perfused brainstem preparation of guinea pig to study central mechanisms of airway defense
2019, Journal of Neuroscience MethodsCitation Excerpt :The burst frequency of the phrenic nerve was lower compared to rats and mice. Nevertheless, the respiratory frequency was in the range of values of previously published data from perfused or decerebrate in vivo guinea pig preparations (Richerson and Getting, 1990; Ohi et al., 2004; Umezaki et al., 2018; Morin-Surun et al., 1992), but lower than anesthetized guinea pig preparations (Canning et al., 2004). Compared to awake guinea pig resting breathing rates of around 80 breaths/min in vivo the average breathing rate of 7 respiratory-cycles/min is indeed low but relates to the low core and brain temperature (31 °C) of the perfused preparation.
Mimicking oxygen delivery and waste removal functions of blood
2017, Advanced Drug Delivery ReviewsSerotonergic mechanisms are necessary for central respiratory chemoresponsiveness in situ
2013, Respiratory Physiology and NeurobiologyCitation Excerpt :The experimental system used in our current study, the unanesthetized, decerebrate arterially perfused in situ juvenile rat brainstem preparation (St.-John and Paton, 2000), retains the integrity of intact respiratory networks in vivo, while avoiding potentially confounding influences of anesthesia or emergent properties of genetically modified model organisms. This preparation retains responsivnbess to CO2-induced changes in pH, albeit with lower sensitivity than the normal in vivo situation, possibly due to the decerebration that is used (Day and Wilson, 2005) or to impaired pH regulation due to a decrease in CO2 transport (Richerson et al., 1990). In the present study, we used the perfused in situ brainstem preparation and pharmacological agents to assess the importance of 5-HT neuromodulation in altering respiratory drive in response to hypercapnia.
Determinants of inspiratory activity
2005, Respiratory Physiology and NeurobiologyThe role of free radicals in cerebral hypoxia and ischemia
2005, Free Radical Biology and Medicine
- *
Present address: Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, U.S.A.