Elsevier

Brain Research

Volume 522, Issue 2, 9 July 1990, Pages 267-274
Brain Research

A subtype of cerebellar Golgi cells may be cholinergic

https://doi.org/10.1016/0006-8993(90)91471-RGet rights and content

Abstract

In cerebellar sections of the feline brain processed for choline acetyltransferase-like immunoreactivity, a population of distinctly stained cells was discovered in the granular layer of the cortex in both vermis and hemispheres. Their position and morphology qualify them as Golgi cells, but their density indicated that they comprise less than 5% of all cerebellar Golgi cells. Varicose immunoreactive fiber nets in all cortical layers also contribute to seemingly widespread cholinergic systems in the cerebellar cortex.

References (54)

  • MesulamM.-M. et al.

    Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1–Ch6)

    Neuroscience

    (1983)
  • OttersenO.P. et al.

    Colocalization of glycine-like and GABA-like immunoreactivities in Golgi cell terminals in the rat cerebellum: a postembedding light and electron microscopic study

    Brain Research

    (1988)
  • PalkovitsM. et al.

    Quantitative histological analysis of the cerebellar cortex in the cat. II. Cell numbers and densities in the granular layer

    Brain Research

    (1971)
  • RibakC.E. et al.

    Immunocytochemical localization of glutamic acid decar☐ylase in neuronal somata following colchicine inhibition of axonal transport

    Brain Research

    (1978)
  • SchulmanJ.A. et al.

    Enkephalin immunoreactivity in Golgi cells and mossy fibers of the mammalian, avian, amphibian and teleost cerebellum

    Neuroscience

    (1981)
  • SmallD.H.

    Acetylcholinesterases: zymogens of neuropeptide processing enzymes?

    Neuroscience

    (1989)
  • SpencerD.G. et al.

    Direct autoradiographic determination of M1 and M2 muscarinic acetylcholine receptor distribution in the rat brain: relation to cholinergic nuclei and projections

    Brain Research

    (1986)
  • VaneyD.I. et al.

    GABA-like immunoreactivity in cholinergic amacrine cells of the rabbit retina

    Brain Research

    (1988)
  • ViziS.E. et al.

    Acetylcholine content in different regions of the rat brain

    Brain Res. Bull.

    (1978)
  • WainerB.H. et al.

    Cholinergic systems in mammalian brain identified with antibodies against choline acetyltransferase

    Neurochem. Int.

    (1984)
  • WilkinG.P. et al.

    Localization of high affinity3H-glycine transport sites in cerebellar cortex

    Brain Research

    (1981)
  • BrownW.J. et al.

    Acetylcholinesterase activity in certain glomeruli and Golgi cells of the granular layer of the rat cerebellar cortex

    Z. Anat. Entwickl.-Gesch.

    (1972)
  • Chan-PalayV.

    Autoradiographic localization of gamma-aminobutyric acid receptors in the rat central nervous system by using [3H]muscimol

  • Chan-PalayV.

    Purkinje cells of the cerebellum: localization and function of multiple neuroactive substances

    Exp. Brain Res.

    (1984)
  • CrawfordJ.M. et al.

    Acetylcholine sensitivity of cerebellar neurons in the cat

    J. Physiol.

    (1966)
  • Csilli´kB. et al.

    Cholinesterase activity of archicerebellar mossy fibre aparatusses

    J. Histochem. Cytochem.

    (1963)
  • DavidoffM.S. et al.

    Coexistence of GABA- and choline acetyltransferase (ChAT)-like immunoreactivity in the hypoglossal nucleus of the rat

    Histochemistry

    (1988)
  • Cited by (37)

    • Nicotine depresses facial stimulation-evoked molecular layer interneuron-Purkinje cell synaptic transmission via α7 nicotinic acetylcholine receptors in mouse cerebellar cortex

      2022, European Journal of Pharmacology
      Citation Excerpt :

      Cholinergic fibers originate from the inferior peduncle and distribute throughout the cerebellar cortex in the form of mossy fibers, glomerular rosettes, and thin varicose fibers (Kan et al., 1978; Illing, 1990; Jaarsma et al., 1997; Ojima et al., 1989).

    • Cerebellum

      2012, The Mouse Nervous System
    • Cerebellum

      2011, The Mouse Nervous System
    • Nicotinic receptor modulation of neurotransmitter release in the cerebellum

      2005, Progress in Brain Research
      Citation Excerpt :

      The finely beaded ChAT-positive fibers have been shown to originate from various nuclei including the pedunculo-pontine tegmental cholinergic nucleus (PPTg), the nucleus raphe obscurus (ROb), and/or the lateral paragiganto cellular nucleus (LPGi) (Jaarsma et al., 1997). Finally, a subset of Golgi cells has been found to be ChAT positive, at least in cat (Illing, 1990) and human (De Lacalle et al., 1993) cerebella. The function of nicotinic receptor activation in the cerebellar circuitry is still largely uninvestigated, although some recent publications suggest that the modulatory role of nAChRs at various synapses could be very important in regulating cell firing and cerebellar output.

    View all citing articles on Scopus
    View full text