[3H]Glycine uptake in rat hippocampus: kinetic analysis and autoradiographic localization
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Cited by (36)
3-aminoglutarate is a "silent" false transmitter for glutamate neurons
2015, NeuropharmacologyCitation Excerpt :All other common laboratory reagents used were supplied by Sigma–Aldrich. A crude synaptosome (P2) fraction was prepared from rat hippocampus as described by Fedele and Foster (1992). Synaptosomes were utilized immediately in transport assays.
The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake
2008, Brain ResearchCitation Excerpt :A similar long linear time course was also observed in JAR cells using the similar assay format (Williams et al., 2003). Under these experimental conditions the calculated Km value of 27 ± 2 μM is similar to the P2 synaptosome (Fedele and Foster, 1992) and human JAR cells, in which GlyT1a was endogenously expressed (Williams et al., 2003). The obtained pharmacology and the PCR analysis (data not shown) confirmed the presence of GlyT1a in the rat primary cortical cells.
Structure, function and regulation of glycine neurotransporters
2003, European Journal of PharmacologyThe glycine transporter-1 inhibitors NFPS and Org 24461: A pharmacological study
2003, Pharmacology Biochemistry and BehaviorChronic high-dose glycine nutrition: Effects on rat brain cell morphology
2001, Biological PsychiatryCitation Excerpt :In addition, various types of stress may increase astrocyte hypertrophy, particularly in the hippocampal dentate gyrus (Sirevaag et al 1991). Because astrocytes are equipped with the metabolic mechanism necessary to cleave GLY (Sato et al 1991) and, in vitro, hippocampal astrocytes are the primary cell group that takes up GLY (Fedele and Foster 1992), astrocytes may represent the first line of cellular adaptation to GLY treatment. Furthermore, GLY promotes GLU release by stimulating presynaptic NMDA receptors (Elliott et al 1995) and affects release of additional neurotransmitters (Mangano et al 1990).