Research reportGlycine-induced changes in synaptic efficacy in hippocampal slices involve changes in AMPA receptors
References (31)
- et al.
Activation of the glycine site in the NMDA receptor is necessary for the induction of LTP
Neurosci. Lett.
(1990) - et al.
Characterisation of LTP induced by the activation of glutamate metabotropic receptors in area CA1 of the hippocampus
Neuropharmacology
(1993) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
Anal. Biochem.
(1976)- et al.
A persistent postsynaptic modification mediates long-term potentiation in the hippocampus
Neuron
(1988) - et al.
Role of receptors in the induction of synaptic potentiation by burst stimulation patterned after the hippocampal theta rhythm
Brain Res.
(1988) - et al.
Modulation of AMPA/quisqualate receptors by phospholipase A2 treatment
Neurosci. Lett.
(1990) - et al.
Postnatal changes in AMPA receptor regulation by phospholipase A2 treatment of synaptic membranes: temporally differential affects on agonist and antagonist binding
Dev. Brain Res.
(1992) - et al.
Effect of bromophenacylbromide, a phospholipase A2 inhibitor, on the induction and maintenance of LTP in hippocampal slices
Brain Res.
(1990) - et al.
Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing
Neuron
(1991) - et al.
Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus
Neuron
(1992)
High concentrations of glycine induce long-lasting changes in synaptic efficacy in rat hippocampal slices
Neurosci. Lett.
Long-term potentiation is associated with increased [3H]AMPA binding in rat hippocampus
Brain Res.
On the locus of the maintenance of long-term potentiation in area CA1 of rat hippocampus
Long-term Potentiation: a Debate of Current Issues
Synaptic Plasticity: Molecular and Functional Aspects
Cited by (22)
Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators
2022, NeuropharmacologyCitation Excerpt :LTP is usually not induced in response to bath application of NMDA alone, but a combination of NMDA, glycine and spermine, which is followed by AP5, produces a slow-onset LTP, which is inhibited by pre-application of AP5 (Thibault et al., 1989). Exogenous application of glycine alone has been also shown to induce a slowly developing LTP in slices from adult rats (Shahi and Baudry, 1993; Shahi et al., 1993) whilst in neonatal slices, in which induction of LTP is unfavourable, glycine induces LTD (Shahi et al., 1993). Glycine-induced LTP was replicated in organotypic cultures (Musleh et al., 1997), dissociated hippocampal neurons (Lu et al., 2001) and also in whole-cell recordings from CA1 hippocampal neurons in slices from juvenile rats (Chen et al., 2011).
Long-term potentiation in cultured hippocampal neurons
2011, Seminars in Cell and Developmental BiologyCitation Excerpt :Therefore, a range of strategies were applied to chemically induce LTP (Chem-LTP) at a majority of synapses. Several of the Chem-LTP induction protocols were originally developed for electrophysiological studies of brain slices [10–16]. However, some of these procedures were successfully adopted and extensively used for the investigation of molecular and cellular events associated with LTP in homogeneous neuronal cultures [8,9].
Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1
2007, NeuropharmacologyCitation Excerpt :Only a few research groups have applied glycine (0.5–10 mM, 10–30 min) in brain slices while recording glutamate-mediated synaptic potentials (Watanabe et al., 1992; Shahi and Baudry, 1993; Shahi et al., 1993; Musleh et al., 1997; Platt et al., 1998). In all these cases they observed that glycine induced a long-term synaptic potentiation (LTP-GLY), which, at least in the Baudry's group results (Shahi and Baudry, 1993; Shahi et al., 1993), appeared to be due to the activation of the glycine site in the NMDA receptor. This is an important issue because NMDA receptors are considered to play a crucial role in the long-term synaptic changes involved in memory and learning (Bliss and Collingridge, 1993; Martin and Morris, 2002).
Suppression of presynaptic responses to adenosine by activation of NMDA receptors
2001, European Journal of PharmacologyGlycine causes increased excitability and neurotoxicity by activation of NMDA receptors in the hippocampus
1997, Experimental Neurology