Involvement of spinal κ opioid receptors in a type of footshock induced analgesia in mice
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Experiences and reflections about behavioral pain assays in laboratory animals
2023, Journal of Neuroscience MethodsEstrogens as arbiters of sex-specific and reproductive cycle-dependent opioid analgesic mechanisms
2019, Vitamins and HormonesCitation Excerpt :This realization suggests that the spinal application of fadrozole (an aromatase inhibitor) or selective antagonists of mERα, mERβ, or GPR30 are likely to be effective adjuvants with intrathecal morphine in these situations. Dynorphin and KOR have been proposed to be pronociceptive (pain promoting) (Dubner & Ruda, 1992; Hollt, Haarmann, Millan, & Herz, 1987; Lai, Ossipov, Vanderah, Malan, & Porreca, 2001; Ruda, Iadarola, Cohen, & Young III, 1988; Stiller, Grubb, & Schaible, 1993; Wang et al., 2001) as well as antinociceptive (pain reducing) (Guirimand, Strimbu-Gozariu, Willer, & Le Bars, 1994; Han & Xie, 1982; Herman & Goldstein, 1984; Menendez, Andres-Trelles, Hidalgo, & Baamonde, 1993; Pelissier, Paeile, Soto-Moyano, Saavedra, & Hernandez, 1990; Przewlocki et al., 1983; Schmauss, 1987; Schmauss & Yaksh, 1984; Watkins, Wiertelak, & Maier, 1992). Formation of spinal cord MOR/KOR heterodimers provides a way to adjust the balance between antinociceptive vs. pronociceptive functions of the spinal dynorphin/KOR opioid system.
Stress-induced modulation of pain: Role of the endogenous opioid system
2018, Progress in Brain ResearchCitation Excerpt :Further evidence supporting this idea came from a study where it was shown that microinjection of dynorphin A (1–13) or its analogue dynorphin A (1–10) amide into the brain enhanced SIA in mice exposed to forced swimming and whole body vibration, but not those exposed to weak immobilization stress, thus indicating that a relatively more severe stress may recruit KOP to potentiate SIA (Starec et al., 1996). Moreover, Menendez et al. (1993a) reported that SIA elicited by foot shock stress in mice was not inhibited by naloxone when administered via the intracerebroventricular route, while intrathecally administered nor-BNI reversed SIA, implicating spinal KOP in the mediation of SIA. Similarly, binaltorphimine (another selective KOP antagonist) injected intrathecally attenuated early- and late-phase analgesia evoked by tail shock stress in rats (Watkins et al., 1992b).
Stress and Opioid Systems
2017, Hormones, Brain and Behavior: Third EditionAntinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice
2011, Journal of EthnopharmacologyCitation Excerpt :The number of animals was kept at a minimum compatible with consistent effects of the drug treatment. A modification of the method of Menéndez et al. (1993) was used. In this case, the animals were free to move and the assay temperature was 45 ± 1 °C.
Dynorphin, stress, and depression
2010, Brain ResearchCitation Excerpt :Dynorphin has also been implicated in neuropathic pain via actions at KORs, as well as at non-opioid receptors, in the spinal cord (Malan et al., 2000; Lai et al., 2001; Wang et al., 2001; Xu et al., 2004, 2007; Gaveriaux-Ruff et al., 2008). Numerous physical and psychological stressors produce analgesic effects (stress-induced analgesia) in rodents that are mediated by KORs (Takahashi et al., 1990; Watkins et al., 1992; Menendez et al., 1993; McLaughlin et al., 2006b). Although KOR-mediated analgesia may aid in physical responses to threat, it is possible that concurrent KOR signaling in limbic brain regions contributes to the increased incidence of depression and anxiety in individuals experiencing chronic pain or stress (Kessler, 1997; Heim and Nemeroff, 1999; Bair et al., 2003; Gureje, 2008).
This work has been supported by a grant of the Universidad de Oviedo (DF91/21940).