Rabbit cerebellar slice analysis of long-term depression and its role in classical conditioning
Reference (23)
- et al.
Excitatory amino acid receptors of cerebellar Purkinje cells: development and plasticity
Prog. Biophys. Mol. Biol.
(1991) - et al.
Long-term depression of parallel fiber synapses following stimulation of climbing fiber
Brain Res.
(1985) - et al.
Stimulation parameters influencing climbing fibre induced long-term depression of parallel fibre synapses
Neurosci. Res.
(1989) - et al.
Acquisition of classical conditioning without cerebellar cortex
Behav. Brain Res.
(1989) - et al.
Learning-specific differences in Purkinje-cell dendrites of lobule HVI (lobulus simplex): intracellular recording in a rabbit cerebellar slice
Brain Res.
(1991) - et al.
Dendritic plateau potentials in Purkinje cells by parallel fibre volleys in the cat
J. Physiol.
(1983) - et al.
Pairing of pre- and postsynaptic activities in cerebellar Purkinje cells induces long-term changes in synaptic efficacyin vitro
J. Physiol.
(1991) - et al.
The Cerebellum as a Neuronal Machine
- et al.
Prolonged dendritic depolarizations elicited in Purkinje cell dendrites by climbing fibre impulses in cat
J. Physiol.
(1981) The Cerebellum and Neural Control
Long-term depression
Annu. Rev. Neurosci.
Cited by (45)
Intracerebellar cannabinoid administration impairs delay but not trace eyeblink conditioning
2020, Behavioural Brain ResearchCitation Excerpt :How might the plasticity mechanism underlying trace EBC be more resistant to the effects of cannabinoids than the mechanism underlying delay EBC? in vitro studies of LTD demonstrate that stronger parallel fiber stimulation, recruiting more parallel fibers, results in increased intracellular calcium by activation of voltage-gated calcium channels, which supports stronger LTD and heterosynaptic LTD at unstimulated synapses [71–73]. The resistance of trace EBC to cannabinoids might therefore be related to the recruitment of more parallel fibers relative to delay EBC.
Changes in cerebellar intrinsic neuronal excitability and synaptic plasticity result from eyeblink conditioning
2019, Neurobiology of Learning and MemoryCitation Excerpt :Publication by R.F. Thompson of a circuit diagram of the essential input and output pathways of the rabbit eyblink (Thompson, 1986) that included the cerebellum (reimagined in Fig. 1) suggested that, like the hippocampus (Coulter et al., 1989; Schwartzkroin, 1975), brain slices might be cut through the cerebellum (Llinas & Sugimori, 1980a,1980b) to record changes in cells involved in the eyeblink conditioning circuit. In the 1990s we developed and began to record from Purkinje cells in slices of cerebellar cortex following eyeblink conditioning (Schreurs & Alkon, 1993; Schreurs, Sanchez-Andres, & Alkon, 1991, 1992). Because of technical issues, most notably the unusually dense perineuronal net surrounding over 90% of neurons in the deep cerebellar nuclei (Blosa et al., 2016; Carulli, Rhodes, & Fawcett, 2007; Mueller, Davis, Sovich, Carlson, & Robinson, 2016), it would be another 15 years before we were able to successfully use whole-cell patch clamp recording techniques to record from neurons in the deep cerebellar nuclei of young rats (Wang & Schreurs, 2014).
Cerebellar learning mechanisms
2015, Brain ResearchCitation Excerpt :These learning-related changes in Purkinje cell simple spike activity suggest that pauses in simple spike firing during the CS release the deep nuclei from tonic inhibition and thereby facilitate CR expression, as would be expected for and LTD-like mechanism (Mauk and Donegan, 1997; Raymond et al., 1996b). The feasibility of parallel fiber LTD as a putative mechanism underlying eyeblink conditioning was examined in vitro with forward paired presentations of parallel fiber and climbing fiber stimulation (Chen and Thompson, 1995; Freeman et al., 1998b; Schreurs and Alkon, 1993; Schreurs et al., 1996). The cellular and molecular mechanisms underlying Purkinje cell LTD were then examined in vivo.
Neurotransmitter release during delay eyeblink classical conditioning: Role of norepinephrine in consolidation and effect of age
2009, Neurobiology of Learning and MemoryThe role of the cerebellum in classical conditioning of discrete behavioral responses
2009, NeuroscienceCitation Excerpt :They observed a conditioning-specific increase in the excitability of Purkinje cell dendrites indicating that the firing properties of these neurons had changed after training. Schreurs and Alkon (1993) developed a more reduced preparation and made intradendritic recordings from Purkinje cells obtained from rabbit cerebellar slices. Direct stimulations of parallel fibers and climbing fibers were used to conjunctively activate the Purkinje cells.
Long-term potentiation of the responses to parallel fiber stimulation in mouse cerebellar cortex in vivo
2009, NeuroscienceCitation Excerpt :Another important issue is the role of GABAA receptors and the molecular layer inhibitory interneurons. As noted, most previous studies of PF–PC LTP or LTD invariably used GABAA antagonists (however, see; Chen and Thompson, 1995; Schreurs and Alkon, 1993). In fact, blocking GABAA receptors is generally considered a requirement for the generation of both forms of plasticity in vitro.