Elsevier

Brain Research

Volume 636, Issue 1, 4 February 1994, Pages 126-130
Brain Research

Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study

https://doi.org/10.1016/0006-8993(94)90186-4Get rights and content

Abstract

Electrophysiological studies suggest that an increase in excitatory amino acid release may occur in the locus coeruleus during opiate withdrawal. The present study examined directly by microdialysis in anesthetized rats the effect of naltrexone-precipitated opiate withdrawal on the efflux of excitatory amino acids in the locus coeruleus. A withdrawal-induced increase in glutamate and aspartate efflux was found when the microdialysis probe was located in the core of the locus coeruleus; no increase was seen in adjacent regions.

References (27)

Cited by (194)

  • Opioid withdrawal and memory consolidation

    2020, Neuroscience and Biobehavioral Reviews
  • Role of orexin type-1 receptors in paragiganto-coerulear modulation of opioid withdrawal and tolerance: A site specific focus

    2017, Neuropharmacology
    Citation Excerpt :

    Consistently, in a recent study by Kaeidi et al. (2015), it was observed that the net naloxone–induced increase in firing rate and resting membrane potential of LC neurons in slices containing both LPGi and LC neurons are significantly higher than slices lacking intact LPGi afferents. Third, glutamate and aspartate efflux has been shown to increase during opiate withdrawal within the LC (Aghajanian et al., 1994; Zhang et al., 1994). Several lines of evidence support the involvement of the LPGi in mediating opiate dependence and tolerance (Ahmadi-Soleimani et al., 2014; Ghaemi-Jandabi et al., 2014; Haghparast et al., 1998; Johnson et al., 2002; Saiepour et al., 2001; Sinchaisuk et al., 2002; Zhu and Zhou, 2010).

View all citing articles on Scopus
View full text