Elsevier

Brain Research

Volume 648, Issue 2, 20 June 1994, Pages 347-351
Brain Research

A comparison of (+) SK & F 10047 and MK-801 on cortical spreading depression

https://doi.org/10.1016/0006-8993(94)91140-1Get rights and content

Abstract

MK-801 and (+)SK & F 10047 produced a dose-related inhibition of the EEG suppression and cortical hyperemia associated with cortical spreading depression (CSD) and reduced the CSD propagation rate; ED50 = 1mg/kg, i.v. and15mg/kg, i.v., respectively. MK-801 had a delayed onset of action (inversely related to dose) and a prolonged duration of action at all doses (> 2h). In contrast, (+)SK & F 10047 had a rapid onset of action (< 30min) and a predictable dose-related duration of action. These results suggests that an efficacious compound acting with moderate affinity as a non-competitive antagonist at the NMDA-receptor channel may possess a preferable time-course and toxicity profile when compared to agents acting similarly, but with high affinity.

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