A comparison of (+) SK & F 10047 and MK-801 on cortical spreading depression
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Propofol hemisuccinate suppresses cortical spreading depression
2012, Neuroscience LettersCitation Excerpt :In the present study, we sought to determine if PHS can affect CSD elicited in vivo in the mouse by cortical application of KCl. As an active comparator, we used the potent uncompetitive NMDA receptor antagonist dizocilpine (MK-801), which is well recognized to suppress CSD [18,21,23,30]. Our results demonstrate that a single acute dose of PHS is effective in suppressing CSD.
Effects of early aging and cerebral hypoperfusion on spreading depression in rats
2011, Neurobiology of AgingCitation Excerpt :This reduced cortex susceptibility to CSD in Middle-age rats agrees with the slower CSD propagation that was previously demonstrated in 24-month-old rats as compared with 3-month-old rats (Guedes et al., 1996). Indeed, slower propagation was found associated with CSD inhibition in a number of previous studies in vivo (Willette et al., 1994; Takaoka et al., 1996; Sonn and Mayevsky, 2001). This decreased sensitivity to CSD in Middle-aged rats contrasts with the previous notion that CSD latency may become shorter with aging as a result of a decreasing threshold of CSD elicitation, due to interstitial space shrinkage that would imply a lower dilution capacity for extracellular K+ (Somjen, 2001).
N-methyl-d-aspartate receptor antagonists for migraine: A potential therapeutic approach
2009, Medical HypothesesSigma receptor agonists provide neuroprotection in vitro by preserving bcl-2
2007, Anesthesia and AnalgesiaPhysiological studies of cortical spreading depression
2006, Biological Reviews of the Cambridge Philosophical Society