Elsevier

Brain Research

Volume 637, Issues 1–2, 21 February 1994, Pages 342-344
Brain Research

Repeated D1 receptor agonist treatment blocks cocaine-induced locomotor activity and c-fos expression

https://doi.org/10.1016/0006-8993(94)91258-0Get rights and content

Abstract

Pretreatment of rats for 4 dyas with the selective dopamine D1 receptor agonist A-77636 attenuated the ability of cocaine to induce locomotor hyperactivity and to stimulate the expression of the proto-oncogene c-fos in the striatum and nucleus accumbens. Our results suggest that repeated D1 agonist treatment leads to subsensitivity of D1 receptors involved in mediating some of the effects of cocaine on behavior and gene expression.

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    These results demonstrated that stimulation of D1 receptors within the Acb shell can enhance EtOH-seeking behavior, and provided further evidence that D1 receptors within the Acb shell, but not the Acb core, are involved in regulating EtOH-seeking behavior of P rats under spontaneous recovery conditions. Several studies have reported effects of A-77636 on cocaine- induced expression of c-Fos in the Acb and striatum (Asin et al., 1994), cocaine-induced locomotor activity (Asin et al., 1994; Chausmer and Katz, 2002), and cocaine drug discrimination tests (Chausmer and Katz, 2002). The current study is the first that examined the effects of A-77636 on EtOH-seeking behavior.

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