Elsevier

Brain Research

Volume 639, Issue 1, 7 March 1994, Pages 167-170
Brain Research

Repeated stress causes reversible impairments of spatial memory performance

https://doi.org/10.1016/0006-8993(94)91778-7Get rights and content

Abstract

Restraint stress, 6 h/day for 21 days, caused an impairment, during acquisition, of the performance of a spatial memory task, the eight-arm radial maze. The impairment was reversible, temporally limited and blocked by phenytoin, a blocker of excitatory amino acid action, or tianeptine, an antidepressant, which lowers extracellular serotonin. These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.

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