Research reportProtection from neuronal damage induced by combined oxygen and glucose deprivation in organotypic hippocampal cultures by glutamate receptor antagonists
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Neuroprotection against supra-lethal ‘stroke in a dish’ insults by an anti-excitotoxic receptor antagonist cocktail
2022, Neurochemistry InternationalCitation Excerpt :This failure concept also applies to the well-known neuroprotective effect of extracellular acidity against OGD in cultured neurons (Fig. 1E) (Giffard et al., 1990; Tombaugh and Sapolsky, 1990), ascribed primarily to proton inhibition of NMDA receptors (Tang et al., 1990), since neuroprotection dissipates with increased OGD duration (Kaku et al., 1993). This concept applies to other NMDARA's (Obeidat et al., 2000), and extends to in vivo studies (Buchan et al., 1991; Nellgård et al., 1991; Strasser and Fischer, 1995). Fifth, antagonists of other receptors also display these trait of decreasing effectiveness with longer durations of OGD, thereby requiring higher concentrations, which nonetheless plateau and eventually are rendered ineffective for a sufficiently severe insult (Strasser and Fischer, 1995; Pringle et al., 1997).
Molecular and cellular mechanisms of ischemia-induced neuronal death
2011, Stroke: Pathophysiology, Diagnosis, and Management