Quantitative analysis of factors influencing neuronal necrosis induced by MK-801 in the rat posterior cingulate/retrosplenial cortex
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2021, Neurotoxicology and TeratologyDifferential Effects of Extended Exercise and Memantine Treatment on Adult Neurogenesis in Male and Female Rats
2018, NeuroscienceCitation Excerpt :Alternatively, while MEM is therapeutically attractive given its positive effects on hippocampus-dependent learning (Zajaczkowski et al., 1996; Zoladz et al., 2006; Ishikawa et al., 2014) and neuroprotective functions (Creeley et al., 2006), it alters the migration of adult-born neurons (Namba et al., 2011) and mMEM treatments may lose their neurogenic effects due to off target effects. A different NMDAR antagonist, MK-801, dose-dependently increases necrosis in the neocortex and these effects are particularly pronounced in females (Fix et al., 1995). While MEM has been reported to be relatively innocuous compared to MK-801, MEM concentrations in serum and brain are twice as high in females as compared to males after intraperitoneal injection (Zajaczkowski et al., 2000).
Expression of heat shock protein HSP-70 in the retrosplenial cortex of rat brain after administration of (R,S)-ketamine and (S)-ketamine, but not (R)-ketamine
2018, Pharmacology Biochemistry and BehaviorCitation Excerpt :Animals were housed under controlled temperatures and 12 h light/dark cycles (lights on between 07:00–19:00 h), with ad libitum food (CE-2; CLEA Japan, Inc., Tokyo, Japan) and water. In this study, we used female rats since female rats are known to be more sensitive than male rats to the neurotoxic effects of the NMDAR antagonists (Farber et al., 1995; Fix et al., 1995; Matsuki et al., 2001). The protocol was approved by the Chiba University Institutional Animal Care and Use Committee (Permission number: 30–324).
N-Methyl-D aspartate receptor-mediated effect on glucose transporter-3 levels of high glucose exposed-SH-SY5Y dopaminergic neurons
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