Sleep and nitric: oxide: effects of 7-nitro indazole, inhibitor of brain nitric oxide synthase
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Cited by (57)
The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N<sup>G</sup>-nitro-l-arginine methyl ester administered alone or jointly with l-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats
2015, Brain ResearchCitation Excerpt :However, due to the fact that the unilateral lesion of the nigrostriatal dopaminergic pathway itself significantly affected the studied parameters of locomotor activity, the action of 7-NI in this group was less evident than in the sham-operated group. Sedative effect of 7-NI associated with motor deficits was also described in other studies (Moore et al., 1993; Dzoljic et al., 1996). In contrast to 7-NI, after 10 min of measurement l-NAME at a dose of 50 mg/kg did not affect any of the studied parameters of locomotor activity in the sham-operated group.
Nitric oxide in the regulation of the sleep-wake states
2012, Sleep Medicine ReviewsCitation Excerpt :As these data have been previously reviewed,6 we summarize only the principal findings: nNOS inhibitors, including the most selective compound identified to date, 3-bromo-7-nitroindazole (7-NI), administered either i.p.81–83 or locally into sleep-permissive or sleep-executive structures, i.e., nRD,82 LDT,84 and PPT,85 significantly decrease SWS, SWA activity during SWS and REM sleep. Transgenic mice with a nNOS-targeted disruption show a REM sleep deficit compared to control wild-type animals.86
Inhibitory effects of fruit extracts on nitric oxide-induced proliferation in MCF-7 cells
2011, Food ChemistryCitation Excerpt :Lopez et al. (2004) showed that administration of the nitric oxide synthase inhibitor, 546C88, resulted in adverse effects, including, decreased cardiac output, pulmonary hypertension, systemic arterial hypertension, heart failure and increased mortality in septic shock patients. 7-Nitro indazole, an inhibitor of central nitric oxide synthase, induces depression, motor deficit and decrease in sleep stages (Dzoljic, de Vries, & van Leeuwen, 1996). NG-nitro-l-arginine methyl ester (l-NAME), an inhibitor of inducible nitric oxide synthase, dose dependently induced motor deficits in mice models (Araki et al., 2001).
Effects of selective neuronal nitric oxide synthase inhibition on sleep and wakefulness in the rat
2006, Progress in Neuro-Psychopharmacology and Biological PsychiatryThe effects of intracerebroventricular application of 8-Br-cGMP and LY-83,583, a guanylyl cyclase inhibitor, on sleep-wake activity in rats
2005, Brain ResearchCitation Excerpt :Several lines of evidence support the notion that NO production in the brain has a role in regulating vigilance. Systemic [14,26,27,39,48] or icv [26,27,39] injection NOS inhibitors or microinjections of NOS inhibitors into the SCN, subparaventricular zone [46] and MPA [44], lateral basal forebrain region [54], diagonal band of Broca [38], laterodorsal tegmentum [25], pedunculopontine tegmentum [12,20,31], and raphe [4,40] and the stimulation of NO-receptive mechanisms by the icv injection [24,37] or microinjection of NO donors into the MPA [44], SCN [46], and pedunculopontine tegmentum [12,20] all modulate sleep. Neuronal and inducible NOS knock-out mice show less REMS and NREMS [7], respectively, and neuronal NOS knock-out mice fail to mount sleep responses to tumor necrosis factor [9] or viral challenge [8].
Nitric oxide and sleep
2005, Sleep Medicine Reviews