Full paperSequence, biochemical characterization, and developmental expression of a new member of the TGF-β superfamily in Drosophila melanogaster☆
References (72)
- et al.
The cell biology of transforming growth factor β
Biochim. Biophys. Acta
(1990) The mammalian subtilisins: The long-sought dibasic processing endoproteases
Cell
(1991)- et al.
An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters
Cell
(1988) Localized cell death caused by mutations in a Drosophila gene coding for a transforming growth factor-β homolog
Dev. Biol
(1988)- et al.
Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells
Cell
(1986) - et al.
Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
Cell
(1990) TGF-β related genes in Drosophila and vertebrate development
Curr. Opin Cell Biol
(1991)- et al.
Identification of a novel transforming growth factor-β (TGF-β5) mRNA in Xenopus laevis
J. Biol. Chem
(1990) - et al.
Transcriptional activation and repression by ultrabithorax proteins in cultured Drosophila cells
Cell
(1989) - et al.
The DVR gene family in embryonic development
Trends Genet
(1991)
Expression cloning of an activin receptor, a predicted transmembrane serine kinase
Cell
TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights
Cell
Differential expression of genes encoding TGFs β1, β2, and β3 during murine palate formation
Dev. Biol
Identification and immunochemical analysis of biologically active Drosophila P element transposase
Cell
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione-S-transferase
Gene
Decapentaplegic: A gene complex affecting morphogenesis in Drosophila melanogaster
Cell
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures
Cell
A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-β
Cell
A simple, rapid method for the purification of poly A+ RNA
BioTechniques
Vectors containing a prokaryotic dihydrofolate reductase gene transform Drosophila cells to methotrexate-resistance
EMBO J
Characterization and use of the Drosophila metallothionein promoter in cultured Drosophila melanogaster cells
Nucleic Acids Res
The Embryonic Development of Drosophila melanogaster
Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebrates
Nucleic Acids Res
Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone
Assembly of the mitochondrial membrane system
J. Biol. Chem
Human transforming growth factor-β cDNA sequence and expression in tumor cell lines
Nature
A new type of transforming growth factor-β: TGF-β3
EMBO J
A comprehensive set of sequence analysis programs for the VAX
Nucleic Acids Res
Cloning and sequence analysis of cDNA species coding from the two subunits of inhibin from bovine follicular fluid
The decapentaplegic gene: A TGF-β homologue controlling pattern formation in Drosophila
Development (Suppl.)
Role of transforming growth factor-β in the development of the mouse embryo
J. Cell Biol
Developmental functions of decapentaplegic, a member of the TGF-β family in Drosophila
Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis
The decapentaplegic gene is required for dorsal-ventral patterning of the Drosophila embryo
Genes Dev
Complementary deoxyribonucleic acid cloning of a messenger ribonucleic acid encoding transforming β4 from chicken embryo chondrocytes
Mol. Endocrinol
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Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preferences
2017, Journal of Biological ChemistryCitation Excerpt :α-GbbN identified a 10-kDa band that matched the expected size of the NH3-NS fragment on Western blottings of the conditioned media. α-GbbCore detected a 28-kDa fragment, which matched the expected size of the NS-S1 cleavage product, and a previously unidentified prodomain fragment (31). Finally, α-GbbC detected the expected Gbb15 ligand secreted into the media (Fig. 1C).
BMP morphogen gradients in flies
2016, Cytokine and Growth Factor ReviewsCitation Excerpt :Bone morphogenetic proteins (BMPs) belong to one of the best-studied family of morphogens. In Drosophila, there are three BMP-type ligands, Decapentaplegic (Dpp), Screw (Scw), and Glass bottom boat (Gbb) [3–5]. Dpp is the Drosophila homolog of vertebrate BMP2/4, Gbb is the homolog of BMP5/6/7/8, and Scw is a distant relative of the BMP5/6/7/8 subclass, with no clear vertebrate ortholog.
The Drosophila COMPASS-like Cmi-Trr coactivator complex regulates dpp/BMP signaling in pattern formation
2013, Developmental BiologyCitation Excerpt :Our chromatin binding data also leaves open the possibility that the Cmi/Trr complex might directly regulate dpp transcription in a subset of cells along the A/P border in the developing wing, likely in collaboration with sequence-specific transcription factors. In the pupal wing, Dpp (BMP2/4) forms a heterodimer with Gbb, a BMP-5/6/7/8 like protein to carry out Tgfβ signaling (Doctor et al., 1992; Khalsa et al., 1998). Dpp and Gbb signal through two Type I Tgfβ receptors, Sax and Tkv and a type II receptor, Punt (Affolter and Basler, 2007).
Fast-tracking morphogen diffusion
2006, Journal of Theoretical Biology
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This work was supported by grants from the American Cancer Society (NP-612), the NIH (RR06610), and the UW-Madison Graduate School to F.M.H. and by an NCI Cancer Center Core Grant to H. C. Pitot.
- 1
Current address: Dept. of Biological Sciences, Mellon Hall, Duquesne University, Pittsburgh, PA 15282.
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P.D.J. was supported by a fellowship from the NIH.
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F.M.H. is supported by a Faculty Research Award from the ACS.