Full paperGene expression in the Caenorhabditis elegans dauer larva: Developmental regulation of Hsp90 and other genes☆
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Expression profile of heat shock response factors during hookworm larval activation and parasitic development
2015, Molecular and Biochemical ParasitologyCitation Excerpt :Over the 24 h incubation period, transcript levels of Aca-daf-21 were higher in non-activated than in activated larvae, with a significant increase in the difference after 12 h. We expected Aca-daf-21 to be more highly expressed in non-activated larvae than in activated larvae as it was shown to be up-regulated in dauer larvae of C. elegans [46,47]. However, expression is down regulated initially in both activated and non-activated L3, and only begins to increase at 12–16 h in non-activated L3.
Regulatory role of the 90-kDa-heat-shock protein (Hsp90) and associated factors on gene expression
2014, Biochimica et Biophysica Acta - Gene Regulatory MechanismsCitation Excerpt :In species such as Saccharomyces cerevisiae, the sequence homology of the two isoforms is as high as 97% [20]. Organisms including Caenorhabditis elegans [21] and D. melanogaster [22] have a single Hsp90 gene, whereas some plants such as rice (Oryza sativa) have four [23]. Hsp90 accounts for ~ 2% of the total soluble proteins in resting cells, ~ 6–7% in cancer cells, and up to 10% in stressed cells or organisms [24–28].
Assessment of the viability of Cryptosporidium parvum oocysts with the induction ratio of hsp70 mRNA production in manure
2013, Journal of Microbiological MethodsHsp90 in non-mammalian metazoan model systems
2012, Biochimica et Biophysica Acta - Molecular Cell ResearchMetazoan operons accelerate recovery from growth-arrested states
2011, CellCitation Excerpt :Transcription rate is often described by the Hill function: β = βmax·TMn / (Kn+TMn) or in its dimensionless form: β/βmax = (TM/K)n/(1n+(TM/K)n), wherein β is transcription rate, TM/K is the normalized concentration of the transcriptional machinery (K denotes the concentration of TM, which enables 50% of maximal transcription rate), and n is the Hill coefficient. Transcription during dauer state was measured and found to be ∼15% of its maximal value (Dalley and Golomb, 1992). We also find that, during the dauer state, many components that make up the transcriptional machinery are found at 50%–60% of their levels as found in growing worms with maximal transcription rate (Figure 2).
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This work was supported by a grant from the National Science Foundation (DMB 8518668) and by Weldon Spring grant 89-WS-067 from the University of Missouri to M.G.