Pharmacology of dopamine D3 receptors in the islands of Calleja of the rat using quantitative receptor autoradiography

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Abstract

The pharmacological properties of [3H]7-hydroxy-N, N-di--n-propyl-2-aminotetralin ([3H]7-OH-DPAT) binding sites in the islands of Calleja of the rat were studied using quantitative receptor autoradiography. The KD and the Bmax values of [3H]7-OH-DPAT binding were about 1.6 nM and 100 fmol/mg protein, respectively. The rank order of potency was R(−)-propylnorapomorphine > 7-OH-DPAT ≈ haloperidol > raclopride > dopamine > remoxipride. Remoxipride injected in vivo (0.03–100 μmol/kg i.p., 1 h before decapitation) did not inhibit subsequent [3H]7-OH-DPAT binding. These results indicate that the pharmacological profile of dopamine D3 receptors in the islands of Calleja of the rat resembles that obtained from cell lines or membrane preparations.

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    Of particular interest would be to know the site(s) of action where SR 21502 reduces cocaine-induced CPP. Dopamine D3 receptors have been localized to the nucleus accumbens and ventral putamen [41,42], globus pallidus [41], ventral pallidum [41,43,44], islands of Calleja [45–47], central nucleus of the amygdala [41,48], and the ventral tegmental area (VTA) [49–51]. Thus, it appears plausible that SR 21502 may produce its effects on cocaine cues in one or more of these neuroanatomical areas.

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