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Adenosine release in the ventral striatum of the rat is modulated by endogenous nitric oxide

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Abstract

The influence of nitric oxide (NO) on adenosine release was investigated by the push-pull technique in the ventral striatum of the urethane-anaesthetized rat. Superfusion with the NO donor diethylamine-NO enhanced, whereas superfusion with the NO synthase inhibitor l-NG-nitroarginine methyl ester decreased the output of adenosine. The effect of l-NG-nitroarginine methyl ester was abolished by l-arginine methyl ester. These findings indicate that, in the ventral striatum of the rat, NO modulates adenosine release.

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