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Histological characterization and quantification of newborn cells in the adult rodent brain
2021, STAR ProtocolsCitation Excerpt :It is an approach that has contributed fundamentally to our understanding of cellular proliferation and differentiation during neurodevelopment as well as in the postnatal brain in both physiological and pathological settings. The technique has evolved from the use of tritiated thymidine followed by autoradiographic detection in the 1960-70s (Sidman, Miale and Feder, 1959; Sidman, 1970), to what are now more routinely used immunohistochemical procedures, where combinations of antibodies allow for the detailed phenotyping of birth-dated cells (for review see (Rowell and Ragsdale, 2012)). The most widely used thymidine analog has been 5-bromo-2′-deoxyuridine (BrdU) (Miller and Nowakowski, 1988), and there are a variety of commercially available antibodies for specific immunochemical detection of BrdU in cell culture or tissue preparations.
Congenital and postnatal microcephalies
2020, Neurodevelopmental Disorders: Comprehensive Developmental NeuroscienceCommon techniques and methods for screening of natural products for developing of anticancer drugs
2020, Evolutionary Diversity as a Source for Anticancer MoleculesOn the proliferation of cell proliferation tests
2020, Handbook of Biomaterials BiocompatibilityFunctional multipotency of stem cells: Biological traits gleaned from neural progeny studies
2019, Seminars in Cell and Developmental BiologyCitation Excerpt :Although his theoretical opinion on the overall issue of neurogenesis/neural regeneration was in fact ambiguous and there were other investigators who held different opinions, it was impossible, with the resources and methods obtainable then, to prove that certain postnatally born cells were actually neurons and not glia [2]. In 1959, a new method of labeling dividing cells in the mammalian brain was developed [3]. The method was based on the already known fact that [H3]-thymidine injected systemically in mammals would be incorporated selectively into replicating DNA of cells during S-phase of the mitotic cycle [4,5].
The “beginnings” of the neural crest
2018, Developmental Biology
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The present address of Drs. Sidman and Feder is: Laboratory of Cellular Neuropathology, Harvard Medical School, Boston 15, Massachusetts, where the final stage of this investigation was carried out with partial support by Grants No. B 1938 and No. NT 271 from the National Institute of Neurological Diseases and Blindness.