Elsevier

Experimental Neurology

Volume 9, Issue 4, April 1964, Pages 286-304
Experimental Neurology

Cortical cellular phenomena in experimental epilepsy: Interictal manifestations

https://doi.org/10.1016/0014-4886(64)90025-1Get rights and content

Abstract

Acute epileptogenic foci have been produced in the cerebral cortex of cats (cerveau isolé or lightly anesthetized preparations) with topical application of penicillin, and the interictal manifestations have been analyzed by means of simultaneous intracellular and surface recording. Within any given neuronal population, individual elements display different degrees of involvement but the most common behavioral pattern of the “epileptic” neuron appears to be a paroxysmal depolarization shift (PDS), often followed by a long-lasting hyperpolarization. The main characteristic features and variations of this pattern are described. Both an excessive synaptic bombardment and (undetermined) changes in the intrinsic properties of the neuronal membrane are likely to contribute to the production of the PDS. This may prevent the soma from being invaded by the spikes but the latter can fire repetitively along the axon. The hyperpolarization shift is probably a true IPSP. Its presence could be one of the limiting factors for the maximal repetition frequency at which the interictal spontaneous discharges can occur.

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Dr. H. Matsumoto's present address is: University of Tokyo School of Medicine, Department of Neuropsychiatry, Motofuji-cho 1, Tokyo, Japan.

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