Spinal cord contusion in the rat: Morphometric analyses of alterations in the spinal cord☆
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2022, Experimental NeurologyThe spatiotemporal spread of cervical spinal cord contusion injury pathology revealed by 3D in-line phase contrast synchrotron X-ray microtomography
2021, Experimental NeurologyCitation Excerpt :Most studies assessing SCI tissue pathology approximate a representation of the overall spinal volume by assessing serial transverse sections that span the injury. Measurements of features within these sections are often then normalised to total cord cross sectional area (compensating for distortion acquired during mechanical processing) and compared after alignment to the injury epicentre (often defined as that section with the greatest degree of tissue damage following injury) (Chen et al. 2016; James et al. 2011; Noble and Wrathall 1985). With full 3D scans, it was instead possible to align cords to root entry zones and compare raw feature measurements.
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2020, Experimental NeurologyInternal decompression of the acutely contused spinal cord: Differential effects of irrigation only versus biodegradable scaffold implantation
2018, BiomaterialsCitation Excerpt :For implantation into rat spinal cords, scaffolds were formed as cylinders with dimensions of 2 mm in length x 1 mm diameter (volume = 1.57 mm3), with just sufficient strength to not disintegrate when being held gently by forceps. The size was based on pilot studies and published literature [79,80]. For minipigs, scaffolds dimensions were 10 mm in length x 2 mm diameter (volume = 31.42 mm3) and the length trimmed if needed.
Locomotor Training Promotes Time-dependent Functional Recovery after Experimental Spinal Cord Contusion
2018, NeuroscienceCitation Excerpt :A 2.5-cm incision in the animal’s back was made using a surgical blade. Spinous process and vertebral lamina were removed to expose the medulla region at T10 spinal level (Noble and Wrathall, 1985). Incomplete SCI was made using the New York University (NYU) Impactor System (Nicola et al., 2016).
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This work was supported by contract NOI-NS-2-2310 from the National Institutes of Health, Bethesda, MD 20205.