An improved device for continuous intraventricular infusions prevents the introduction of pump-derived toxins and increases the effectiveness of NGF treatments
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Cited by (51)
Nerve growth factor restores the expression of vasopressin and vasoactive intestinal polypeptide in the suprachiasmatic nucleus of aged rats
2005, Brain ResearchCitation Excerpt :The cannulae were connected to methylene blue (0.01%, Sigma) filled Alzet osmotic minipumps (model 2002; Alza Corporation, Palo Alto, CA, USA) via sterile coiled polyethylene tubing (PE-60; Intramedic, Becton Dickinson, Sparks, MD, USA). This tubing was filled with air–oil spacer at the pump end [58], and with NGF (150 μg diluted in 150 μl of vehicle). Osmotic minipumps were pre-tested to confirm their delivery rate, and implanted subcutaneously in the neck.
Interleukin-15 administration improves diaphragm muscle pathology and function in dystrophic mdx mice
2005, American Journal of PathologyCitation Excerpt :IL-15 was dissolved in sterile isotonic saline at a concentration of 3.79 mg/ml and loaded into miniosmotic pumps (model 1002; Alzet, Cupertino, CA). Treated mice were implanted with a pump that had been partially dipped in paraffin wax to achieve a pumping rate of ∼0.125 μl/hour (3 μl/day) for 28 days.34 Treated mice received 10 μg of IL-15 per day, approximately equivalent to 0.5 mg/kg/day for a 25 g mouse.
NGF and NT-3 exert differential effects on the expression of neuropeptides in the suprachiasmatic nucleus of rats withdrawn from ethanol treatment
2003, Brain ResearchCitation Excerpt :The cannulae were connected to methylene blue (0.01%, Sigma) filled Alzet osmotic minipumps (model 2002; Alza Corporation, Palo Alto, CA) via sterile coiled polyethylene tubing (PE-60; Intramedic, Becton Dickinson, Sparks, MD). This tubing was filled with air-oil spacer at the pump end [51] and with vehicle (130 μl), NT-3 (130 μg diluted in 130 μl of vehicle) or NGF (65 μg diluted in 130 μl of vehicle). Osmotic minipumps were pre-tested to confirm a delivery rate of 0.5 μl/h, and implanted subcutaneously in the neck.
Improved contractile function of the mdx dystrophic mouse diaphragm muscle after insulin-like growth factor-I administration
2002, American Journal of PathologyCitation Excerpt :This dose was chosen to elicit the beneficial functional effects of IGF-I from previous studies,19,21–23 while minimizing the probability of deleterious side effects associated with elevated circulating IGF-I concentrations.24 IGF-I dissolved in 10 mmol/L of HCl and sterile isotonic saline at a concentration of 8.3 mg/ml was loaded into miniosmotic pumps (model 1002; Alzet, Cupertino, CA) that had been partially dipped in paraffin wax to achieve a pumping rate of 0.125 μl/hour (3 μl/day) for 28 days.25 Loaded pumps were primed in isotonic saline at 37°C for 24 hours before implantation.
Cell delivery to the central nervous system
2000, Advanced Drug Delivery Reviews