Hereditary demyelinating neuropathy in the Trembler mouse

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Abstract

The Trembler mouse suffers from a hereditary demyelinating neuropathy. Nerve conduction studies were performed on the sciatic nerve, median nerve and dorsal nerve of the tail. There was a prolonged terminal latency, and motor conduction velocities were less than 10 m/sec in all the nerves examined. The electrophysiological abnormalities correlate with the pathological findings of hypomyelination.

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This work was supported by grants from the National Health and Medical Research Council of Australia, and from the Postgraduate Medical Foundation, University of Sydney.

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