Research paperThe pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
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Untangle the mystery behind DS-associated AD – Is APP the main protagonist?
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2022, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders, Second EditionCognitive outcome measures for tracking Alzheimer's disease in Down syndrome
2022, International Review of Research in Developmental DisabilitiesCitation Excerpt :The early hallmark features of AD brain pathology, including the accumulation of amyloid-beta (Aβ), are near-universally present in DS by age 40 years (Fortea et al., 2021; Head, Powell, Gold, & Schmitt, 2012; Lao et al., 2017). It is estimated that over half of adults with DS exhibit AD dementia by 55 years of age (Rubenstein, Hartley, & Bishop, 2020) and this rises to 88–100% after age 65 years (Mann & Esiri, 1989). AD has been identified as the proximate cause of death in 70% of cases of adults with DS (Hithersay et al., 2019; McCarron et al., 2017).
Down Syndrome Biobank Consortium: A perspective
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