Thermoregulatory effects of resiniferatoxin in the mouse: Comparison with capsaicin
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Depressive behavior in the forced swim test can be induced by TRPV1 receptor activity and is dependent on NMDA receptors
2014, Pharmacological ResearchCitation Excerpt :Changes in body temperature were used to validate that the low s.c. dose of RTX activates while the higher dose and the intrathecal dose desensitize TRPV1 receptors. A decrease in body temperature 1 h after injection of RTX reflects its agonistic effect [9,35,48,49] that persisted for 24 h after injection of the low s.c. dose of RTX [48,49]. In contrast, the diminished response to repeated injections of the higher s.c. dose of RTX indicates desensitization of thermosensitive receptors [49,50].
TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides
2013, Bioorganic and Medicinal ChemistryCitation Excerpt :Consistent with its in vitro mechanism of action, in vivo 24S also blocked response to capsaicin (Fig. 4). The intraperitoneal injection of 3 mg/Kg capsaicin resulted in a decrease of body temperature as expected,21,22 with a reduction from 37.6 ± 0.1 to 34.0 ± 0.1 °C (p <0.05) at 15 min post capsaicin injection and to 35.8 ± 0.4 °C (p <0.05) at 30 min post capsaicin injection. By 60 min body temperature had returned to normal (37.1 ± 0.1 to 37.0 ± 0.1 °C; p = 1.00).
Resiniferatoxin
2007, xPharm: The Comprehensive Pharmacology ReferenceChapter 4 TRPV1: A Polymodal Sensor in the Nociceptor Terminal
2006, Current Topics in MembranesCitation Excerpt :Moreover, they demonstrated that high‐dose capsaicin administration to neonatal rats could trigger the irreversible degeneration of a specific subset of thin, unmyelinated afferent neurons responsible for pain sensation (Jancso et al., 1967, 1977; Szolcsanyi and Jancso‐Gabor, 1975, 1976; Szolcsanyi, 1977). In the 1980s, Blumberg and colleagues came to the critical realization that capsaicin and resiniferatoxin (RTX) (Fig. 1), a pungent phorbol ester derived from Euphorbia species, share similar chemical structures, including a vanilloid motif that is essential for pungency (deVries and Blumberg, 1989; Szallasi and Blumberg, 1989). These investigators also provided evidence for specific binding of [3H] RTX (and its displacement by capsaicin) to the cell bodies and spinal projections of small‐diameter primary sensory neurons located in the dorsal root and trigeminal ganglia (Szallasi and Blumberg, 1990).