Characterisation and autoradiographic localisation of 5-HT3 receptor recognition sites identified with [3H]-(S)-zacopride in the forebrain of the rat
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Cited by (129)
Autoradiographic labelling of 5-HT<inf>3</inf> receptors in the hemi-parkinsonian rat brain
2022, Neuroscience ResearchSerotonin/dopamine interaction: Electrophysiological and neurochemical evidence
2021, Progress in Brain ResearchCitation Excerpt :The 5-HT3A receptor subunit is the main subunit in the brain and is co-expressed with the 5-HT3B receptor subunit in several neuronal populations of rodents (Morales and Wang, 2002). The initial, anatomical characterizations were obtained with different radioligands (Barnes et al., 1990). The density of the binding sites in the CNS was found to be the highest in the nuclei of the caudal medulla including the area postrema.
Stereological investigation of 5-HT<inf>3</inf> receptors in the substantia nigra and dorsal raphe nucleus in the rat
2021, Journal of Chemical NeuroanatomyCitation Excerpt :We found a lack of 5-HT3A receptor expression at the protein level in the SNc, at least when IHC is employed as the detection technique. This is in line with the prevailing conclusion of others who have attempted to map the distribution of 5-HT3 receptors in the rat with autoradiography, IHC or in situ hybridisation (Barnes et al., 1990; Gehlert et al., 1991, 1993; Geurts et al., 2002; Kilpatrick et al., 1988; Morales et al., 1998, 1996a; Spier et al., 1999; Steward et al., 1993; Waeber et al., 1990). Only one such study found low-level expression of 5HT3 receptors in the SN via antibody radiolabelling (Doucet et al., 1999).
Distribution of 5-HT receptors in the central nervous system: an update
2020, Handbook of Behavioral NeuroscienceSerotonergic modulation of the activity of mesencephalic dopaminergic systems: Therapeutic implications
2017, Progress in NeurobiologyCitation Excerpt :In the CNS, the highest densities of 5-HT3-receptor-binding sites have been detected in several nuclei in the caudal medulla, such as the area postrema, the nucleus of the solitary tract, the dorsal motor nucleus of the vagus, and the nucleus of the spinal tract of the trigeminal nerve. In addition, 5-HT3-receptor-binding sites have been found in the forebrain, albeit at lower densities and with a scattered distribution (Barnes et al., 1990; Hoyer et al., 2002), in DA brain regions such as the SNc and VTA, the mPFC, the NAc and at lower densities in the striatum (Kilpatrick et al., 1996; Laporte et al., 1992; Morales et al., 1998). Furthermore, 5-HT3 receptors were mainly found to be expressed on GABA containing cells in the rat neocortex, olfactory cortex, HIP, and amygdala, and these cells often express cholecystokinin immunoreactivity (Morales et al., 1998, 1996; Morales and Bloom, 1997).
Differential role of the basolateral amygdala 5-HT3 and 5-HT4 serotonin receptors upon ACPA-induced anxiolytic-like behaviors and emotional memory deficit in mice
2014, Behavioural Brain ResearchCitation Excerpt :These effects are thought to be regulated via multiple 5-HT receptor subtypes, thus the behavioral outcomes may notably vary based on the 5-HT receptor subtype involved, the site of administration (central vs. systemic), type of the drugs used, timing of the drug administration, and the behavioral tests employed [35]. 5-HT3 and 5-HT4 serotonin receptors are found in several parts of the brain such as the entorhinal cortex, amygdala and the hippocampus [36–40]. These receptors which extensively express in the amygdala are shown to play a distinctive role in anxiety-like behaviors, learning and memory processes [29,37,39].