Review: Neurotransmitter receptors VINeuronal nicotinic receptors: Molecular organization and regulations
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Cited by (241)
Cation-π Interactions and their Functional Roles in Membrane Proteins: Cation-π interactions in membrane proteins
2021, Journal of Molecular BiologyCitation Excerpt :Soon thereafter, the structure of the acetylcholine esterase demonstrated the biological relevance of a cation-π interaction between ACh and a resident tryptophan in the enzyme.42 Encouragingly, contemporary research established that the binding site of ACh on nAChR was rich in aromatic residues.43 Using their recently developed chemical misacylation approach for nonsense suppression described above, the Lester and Dougherty research groups systematically encoded serially fluorinated tryptophan analogs at the implicated sites and ultimately found a strong cation-π interaction involving a single tryptophan residue, W149, of the α subunit.28
The dynamics of cardiac autonomic control in sleeping preterm neonates exposed in utero to smoking
2016, Clinical NeurophysiologyMode of action of triflumezopyrim: A novel mesoionic insecticide which inhibits the nicotinic acetylcholine receptor
2016, Insect Biochemistry and Molecular BiologyCitation Excerpt :In vertebrates 17 different subunits (α, β, γ, δ, ε) combine as either homomeric (e.g. α7) or heteromeric (e.g. α4β2, α3β4) nAChRs (Millar, 2003). Subunit composition is a significant determinant of receptor pharmacology as well as the degree of desensitization (Giniatullin et al., 2005; Paradiso and Steinbach, 2003; Quick and Lester, 2002; Galzi and Changeux, 1995). At least ten subunits (seven α (Dα1-Dα7) and three β (Dβ1-Dβ3)) have been identified in the fruit fly, Drosophila melanogaster (Jones et al., 2007; Millar, 2003).
α-4 subunit of nicotinic acetylcholine receptor polymorphisms exhibit no association with smoking behavior among Malay Males in Kelantan, Malaysia
2016, Egyptian Journal of Medical Human Genetics