Elsevier

Physiology & Behavior

Volume 11, Issue 4, October 1973, Pages 497-501
Physiology & Behavior

A gene influencing active avoidance performance in mice

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Abstract

Active avoidance learning performance, measured in a shuttle box apparatus, differed significantly in C57BL/6By and BALB/cBy mice. Evaluation of this performance in reciprocal F1 hybrids of these two inbred strains, and in their recently developed recominant inbred strains allowed characterization of a single dominant autosomal gene which influences active avoidance performance. Use of congenic lines B6.C-H-25c and B6.C-H(w56) determined linkage of this gene, Aal, on Chromosome 9 (LG II) of the mouse.

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This study was supported in part by a grant of the Italian and French National Research Councils, in part by Grant HD-05860 from the National Institute of Child Health and Human Development, and in part by Grant GM-15574 from the National Institute of General Medical Sciences.

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The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.

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