The effect of apomorphine on the open-field behavior of rats: Alone and in pairs☆
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Cited by (15)
The dopaminergic D1 receptor modulates the hyperactivity of Bapa mutant mice
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2018, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :The total number during the 3 min period was used to compare the groups (Volosin et al., 1988; Van den Buuse and De Jong, 1989). Grooming frequency: it is the number of face washing and scratching with the hind leg, licking of the fur and genitals during the 3 min interval (Cunha and Masur, 1978; Chow and Beck, 1984). Rearing frequency: it is the number of times the animal stood and stretched on hind limbs with or without fore limb support (Altman et al., 1971; Van den Buuse and De Jong, 1989).
Pharmacological analysis of zebrafish lphn3.1 morphant larvae suggests that saturated dopaminergic signaling could underlie the ADHD-like locomotor hyperactivity
2018, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :In addition, blockade of the D1-like receptor with the specific antagonist SCH-23390 increased locomotion, an observation consistent with the activation of D2-like receptors by endogenous levels of dopamine (Fig. 3C,D). For Apo, our results contrast with prior publications where Apo increases D1 and D2 receptor activity and induces a dose-dependent hyper-locomotion in rodents (Chow and Beck, 1984; Zarrindast and Eliassi, 1991). However at very low doses Apo is preferentially an agonist of D2 auto-receptors, which inhibit DA release and suppress locomotor activity (Carrera et al., 2011; Dias et al., 2006).
Behavioral response profiles following drug challenge with dopamine receptor subtype agonists and antagonists in developing rat
2003, Neurotoxicology and TeratologyEffects of low dosages of apomorphine on maternal responsiveness in lactating rats
2000, Pharmacology Biochemistry and BehaviorDopaminergic brain system in the quaking mutant mouse
1995, Pharmacology, Biochemistry and Behavior
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This research was conducted in partial fulfillment of the requirements for the Masters degree in Psychology of H.L. Chow and was supported by an Alberta Heritage Foundation for Medical Research Studentship award to H.L. Chow and a Medical Research Council of Canada award to C. H. M. Beck.