Antiaversive properties of opioids in the conditioned taste aversion test in rat

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Abstract

The antiaversive effect of μ-, κ- and δ-opioid receptor agonists conditioned taste aversion (CTA) induced by apomorphine, lithium chloride and copper sulphate in the rat was studied, in order to evaluate whether prevention of CTA is a suitable model for the study of antiemetics. Anti-aversion was not a general characteristic of all opioid substances tested. Only one dose of the μ-agonist morphine and only one dose of the κ-agonist ethylketocyclazocine had a consistent antiaversive effect against CTA induced by apomorphine; one dose of the δ-agonist [D-Ala2, Met5]enkephalinamide antagonized the aversion induced by lithium chloride. As the results do not correspond to our previous findings on the antiemetic effects of these opioids in the dog (all μ- and κ-agonists tested having an antiemetic effect), we conclude that the CTA test cannot be used as a screening test for potentially antiemetic drugs.

References (28)

Cited by (8)

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    2014, Behavioural Brain Research
    Citation Excerpt :

    In all CSA experiments rats had access to fluid (0.1% saccharin or water depending on the stage of the experiment) for 20 min daily starting the day before the beginning of experimental procedures and throughout its entire duration. The use of such a fluid restriction protocol is common in CTA studies involving drinking from bottles and is justified by the need to ensure reproducible drinking during a given time interval [36–40]. Animals drank fluid from two special bottles (50 ml capacity), placed inside the home cage by metallic supports.

  • Central opioids and consumption of sweet tastants: When reward outweighs homeostasis

    2007, Physiology and Behavior
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    Relatively few studies have attempted to investigate influence exerted by opioids on the regulation of ingestive behavior in relation to a possible involvement of the OT system. Results published by Blancquaert et al. are of particular interest, as they show that some opioid agonists reduce taste aversion [5]. We observed a similar effect of opioid pretreatment on the development of a conditioned taste aversion (CTA) induced with lithium chloride (LiCl) in rats [41].

  • Molecular targets of lithium action

    2003, Acta Neuropsychiatrica
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Research Associate of the National Fund for Scientific Research (Belgium).

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