Increased adult behavioral ‘despair’ in rats neonatally exposed to desipramine or zimeldine: An animal model of depression?
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Cited by (75)
Perinatal selective serotonin reuptake inhibitor (SSRI) and other antidepressant exposure effects on anxiety and depressive behaviors in offspring: A review of findings in humans and rodent models
2021, Reproductive ToxicologyCitation Excerpt :In terms of perinatal antidepressant medication effects on offspring depressive-like behavior (Table 3), some researchers have reported that perinatal exposure to non-SSRIs reduced depressive-like behaviors in juvenile offspring [52,114], while others failed to find significant effects of perinatal antidepressant medication exposure on depressive-like behavior [69]. Other researchers have reported the perinatal non-SSRI exposure increased depressive-like behaviors in adult offspring [93,95,96,97,115,116]. Conversely, adult female rat offspring with prenatal venlafaxine (37.5 mg/kg) exposure were less depressed (reduced immobility) than male offspring [94].
Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies
2020, Neuroscience and Biobehavioral ReviewsPerinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress
2017, PsychoneuroendocrinologyCitation Excerpt :We have previously shown that perinatal SSRIs may protect against the effects of maternal stress on immobility in the forced swim test and hippocampal neurogenesis in adolescent offspring (Rayen et al., 2011). However, this preventative effect of SSRIs against the effects of maternal stress is not evident during adulthood (Boulle et al., 2016a,b; Rayen et al., 2015; Rayen et al., 2013) and perinatal SSRI treatments to healthy dams and offspring often increase affective-like behaviors in adult offspring (primarily males studied: maternal stress not used) (Glover et al., 2015; Hansen et al., 1997; Hilakivi and Hilakivi, 1987; Pawluski et al., 2015; Rebello et al., 2014; Sarkar et al., 2014). Thus, SSRIs may act to protect against some aspects of maternal stress during the juvenile period and adolescence, but not during adulthood.
Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research
2016, International Journal of Developmental NeuroscienceCitation Excerpt :We found 19 publications that evaluated FST behavior in adult rodent offspring that were exposed to SSRIs during early life. The majority of these studies found that perinatal SSRI exposure increased adult FST immobility (Hilakivi and Hilakivi, 1987; Velazquez-Moctezuma and Diaz Ruiz, 1992; Hansen et al., 1997; Rebello et al., 2014; Sarkar et al., 2014; Lisboa et al., 2007; Glover et al., 2015a; Boulle et al., 2016; Zohar et al., 2015; Bhagya et al., 2015; Yang et al., 2008; Vazquez-Palacios et al., 2005; Limon-Morales et al., 2014); three studies found no effect of perinatal SSRI exposure (Rayen et al., 2011; Coleman et al., 1999; Olivier et al., 2011b), and three reported decreased FST immobility(McAllister et al., 2012; Karpova et al., 2009; Mendes-da-Silva et al., 2002) (Table 2). One quarter of the studies reviewed here examined the effects of perinatal SSRI exposure on mice.
Early-life exposure to the SSRI paroxetine exacerbates depression-like behavior in anxiety/depression-prone rats
2015, NeuroscienceCitation Excerpt :Numerous rodent studies report behavioral and neural abnormalities following perinatal antidepressant exposure. While many findings are consistent across studies, there are discrepancies that likely stem from technical variations, including using different (a) antidepressant drugs [chlorimipramine, fluoxetine, citalopram, paroxetine, desipramine, zimelidine, LU-10-134C, nomifensine]; (b) route of drug administration [oral, intraperitoneal injection, osmotic minipump]; (c) species (mouse/rat) or strain used; and (d) timing of drug administration during pregnancy (Vorhees et al., 1994; Bairy et al., 2007; Forcelli and Heinrichs, 2008; Van den Hove et al., 2008); portions of the first three postnatal weeks (Mirmiran et al., 1981; Hilakivi and Hilakivi, 1987; Hilakivi et al., 1987a,b, 1988; Feenstra et al., 1996; Hansen et al., 1997; Kinney et al., 1997; Vijayakumar and Meti, 1999; Yannielli et al., 1999; Ansorge et al., 2004; Maciag et al., 2006a,b; Popa et al., 2008; Lee, 2009; Weaver et al., 2010; Simpson et al., 2011); or throughout gestation and the first three postnatal weeks (Lisboa et al., 2007; Bourke et al., 2013b). The vast majority of these studies focus on the effects of neonatal antidepressant exposure on male offspring with the exception of perhaps only one or two studies that also examine effects in females (Lisboa et al., 2007; McAllister et al., 2012).