Naloxone's anorectic effect is dependant upon the relative palatability of food
References (24)
- et al.
Naltrexone suppresses hyperphagia induced in the rat by a highly palatable diet
Pharmacol. Biochem. Behav.
(1981) - et al.
Influence of intake of sweet solutions on the analgesic effect of a low dose of morphine in randomly bred rats
Behav. Neural Biol.
(1985) Effects of opiate agonists and antagonists on fluid intake and saccharin choice in the rat
Neuropharmacology
(1983)- et al.
Effects of naltrexone on food preference and concurrent behavioral responses in food-deprived rats
Pharmacol. Biochem. Behav.
(1989) - et al.
Taste responses and preferences for sweet high-fat foods: Evidence for opioid involvement
Physiol. Behav.
(1992) - et al.
Activation of hypothalamic beta-endorphin pools by reward induced by highly palatable food
Pharmacol. Biochem. Behav.
(1983) - et al.
The effects of morphine on diet selection are dependent upon baseline diet preferences
Pharmacol. Biochem. Behav.
(1990) - et al.
Centrally administered opioid peptides stimulate saccharin intake in nondeprived rats
Pharmacol. Biochem. Behav.
(1989) - et al.
Failure of naltrexone to affect the pleasantness of intake of food
Pharmacol. Biochem. Behav.
(1991) - et al.
Flavor enhances the antidipsogenic effect of naloxone
Physiol. Behav.
(1982)
Opiate blockade inhibits saccharin intake and blocks normal preference acquisition
Pharmacol. Biochem. Behav.
Increased fat consumption induced by morphine administration in rats
Pharmacol. Biochem. Behav.
Cited by (95)
Involvement of opioid signaling in food preference and motivation: Studies in laboratory animals
2016, Progress in Brain ResearchCitation Excerpt :Most of these have focused on dietary restraint access by disrupting food intake through restrictions of caloric availability, limiting duration of food access, combining access to food with environmental stress, and intermittingly offering sugar and chow, and each has shown these to be crucial in instigating binge-like behavior (Corwin and Buda-Levin, 2004; Geary, 2003; Giraudo et al., 1993; Hagan et al., 2002, 2003; Howard and Porzelius, 1999; Inoue et al., 2004). Studies using a variety of binge-eating-like behavior models have consistently shown that opioid receptor antagonists, particularly those acting on mu-opioid receptors, reduce or attenuate the expression of binge-like food consumption in animals (Barbano and Cador, 2006; Bodnar et al., 1995; Cooper, 1980; Davis et al., 1983; Giraudo et al., 1993; Glass et al., 2001; Hadjimarkou et al., 2004; Hagan et al., 1997; Kelley et al., 1996; Levine and Billington, 1997). It is still debated whether eating disorders can be thought of as food addictions (Salamone and Correa, 2013) as contention still exists about how the neural signatures of eating disorders are similar to the neuroadaptations that take place in the development of drug addiction (Ifland et al., 2009; Pelchat, 2009; Rogers and Smit, 2000).
Generating positive affective states in sheep: The influence of food rewards and opioid administration
2014, Applied Animal Behaviour ScienceCitation Excerpt :In contrast, administration of naloxone (an opioid antagonist) decreases food intake in rats (Giraudo et al., 1993) and sheep (Alavi et al., 1993, 1991; Verbeek et al., 2012), and is thought to reduce the rewarding properties of palatable foods (Glass et al., 1996). Naloxone has no effect on unpalatable food consumption, except at very high doses (Giraudo et al., 1993; Glass et al., 1996). Previously we have shown that morphine increases locomotor activity and vocalisations in sheep, suggesting that it increases the arousal component of affective states (Verbeek et al., 2012).
Principles of motivation revealed by the diverse functions of neuropharmacological and neuroanatomical substrates underlying feeding behavior
2013, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Systemic administration of opioid agonists increases, and of antagonists decreases, food intake in sated rats (Glass et al., 1999; Bodnar, 2004; Levine and Billington, 2004). Moreover, opioid antagonists, such as naloxone or naltrexone, preferentially decrease the intake of highly palatable, sweet, or fatty foods (Giraudo et al., 1993; Agmo et al., 1995; Cleary et al., 1996; Yeomans and Gray, 1997, 2002; Glass et al., 1999; Kelley et al., 2002; Barbano and Cador, 2005) while opioid agonists, such as morphine or DAMGO, preferentially increase it (Bakshi and Kelley, 1993; Doyle et al., 1993; Zhang and Kelley, 1997). As well, Barbano and Cador (2005) found that the amount of food eaten in sated or restricted rats is not modified after systemic injection of a dopaminergic antagonist (alpha-flupentixol), whatever the degree of palatability of the food and whatever the doses of the neuroleptic used (though these doses were devoid of motor-debilitating effects).
Opioid control of behaviour in sheep: Effects of morphine and naloxone on food intake, activity and the affective state
2012, Applied Animal Behaviour Science