The nucleotide sequence and the tissue-specific expression of Drosophila c-src

doi:10.1016/0092-8674(85)90279-X

Cell

Volume 42, Issue 3, October 1985, Pages 831-840

https://doi.org/10.1016/0092-8674(85)90279-X Get rights and content

Abstract

We have examined the coding capability and expression of the Drosophila homolog of the vertebrate proto-oncogene c-src. Sequence analysis of a cDNA clone representing the Drosophila c-src locus suggests that the gene encodes a 62 kd protein that is remarkably similar to the protein product of chicken c-src. The Drosophila c-src locus is transcribed into three mRNAs that are each regulated independently during development. Drosophila c-src RNA is abundant in embryos and pupae but rare in larvae and adults. In situ hybridization reveals that after the first 8 hr of development, c-src RNA accumulates almost exclusively in neural tissues such as the brain, ventral nerve chord, and eye-antennal discs, and in differentiating smooth muscle. We conclude that c-src may not be a mitotic signal but instead may play a role in the development of neural tissue and smooth muscle.

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Cell

ArticleThe nucleotide sequence and the tissue-specific expression of Drosophila c-src

Abstract

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J. Mol. Biol.

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Devl. Biol.

Cellular oncogenes and retroviruses

Ann. Rev. Biochem.

The postembryonic development of Drosophila

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

J. Virol.

Article
The nucleotide sequence and the tissue-specific expression of Drosophila c-src