Cell
Volume 50, Issue 6, 11 September 1987, Pages 847-861
ArticlePositive and negative regulation of transcription in vitro: Enhancer-binding protein AP-2 is inhibited by SV40 T antigen
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2023, Pathology Research and PracticeAn Osteoporosis Risk SNP at 1p36.12 Acts as an Allele-Specific Enhancer to Modulate LINC00339 Expression via Long-Range Loop Formation
2018, American Journal of Human GeneticsCitation Excerpt :Our results indicated that TFAP2A could particularly bind to rs6426749-G allele to increase the expression of LINC00339. TFAP2A is a transcriptional activator that can bind to enhancer regions to elevate the enhancer activities.70,71 Our knockdown experiment found that downregulation of TFAP2A efficiently repressed LINC00339 expression in osteoblast cells, which provides functional evidence to support the role of transcriptional activation for TFAP2A.
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