Cell
MinireviewEpithelial morphogenesis
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Cited by (185)
Integrated stem cells from apical papilla in a 3D culture system improve human embryonic stem cell derived retinal organoid formation
2022, Life SciencesCitation Excerpt :Mesenchymal cells are located throughout the body, including the bone marrow, adipose tissue, pancreas, lungs, and eyes. They play a pivotal role in epithelialization by secreting growth factors and extracellular matrix components [1]. Control of cellular activities like proliferation, survival and differentiation, along with anti-apoptotic and immunomodulatory potential [2], and secretion of various growth factors [3] make mesenchymal stem cells (MSCs) a unique cell source for different applications.
Functional peptide KP24 enhances submandibular gland tissue growth in vitro
2016, Regenerative TherapyCitation Excerpt :A specific morphological change called branching morphogenesis is observed in the SMG tissue [18,19]. Since such branching morphogenesis can also be observed in other glandular-like tissues, including the lung, kidney, pancreas, and mammary gland tissues [20,21], methods developed for SMG tissue growth modulation may be used for the growth modulation of other tissues as well. In this study, we investigated the ability of a functional peptide to modulate SMG tissue growth in vitro.
Gastric mesenchymal myofibroblasts maintain stem cell activity and proliferation of murine gastric epithelium in vitro
2015, American Journal of PathologyCitation Excerpt :By using our new method, we are now trying to culture the gastric epithelium for an extended period. Epithelial-mesenchymal interaction plays a central role in the morphogenesis, proliferation, and cytodifferentiation of various organs.5 Expression of Gas1, which is expressed in the developing mouse gastrointestinal tract, was significantly higher in GMFs than in IMFs.
Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1
2014, Developmental BiologyExocrine ontogenies: On the development of pancreatic acinar, ductal and centroacinar cells
2012, Seminars in Cell and Developmental BiologyCitation Excerpt :Specifically, 9-cis retinoic acid (9cRA) inhibits acinar differentiation in the developing pancreas, in favor of ducts, and 9cRA does not induce ductal differentiation in the absence of mesenchyme or following inhibition of laminin signaling [69]. Another mesenchyme-derived soluble factor selectively promoting pancreatic ductal proliferation and differentiation is epimorphin (syntaxin 2), which is also known to induce epithelial branching in a variety of tissues [71,72]. Recently, through the use of a mesenchymal-specific Nkx3.2 (Bapx1):Cre driver, the mesenchymal contribution to pancreas development was probed in vivo [73].